{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:05:51Z","timestamp":1791273951086,"version":"4.1.0"},"reference-count":44,"publisher":"American Society for Clinical Investigation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12,19]]},"DOI":"10.1172\/jci88622","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T23:02:36Z","timestamp":1482102156000},"page":"500-510","source":"Crossref","is-referenced-by-count":47,"title":["Gs\u03b1 deficiency in the dorsomedial hypothalamus underlies obesity associated with Gs\u03b1 mutations"],"prefix":"10.1172","volume":"127","author":[{"given":"Min","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogendra B.","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Podyma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Naglieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Gavrilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1497"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-3895"},{"issue":"11","key":"B3","doi-asserted-by":"crossref","first-page":"E1796","DOI":"10.1210\/jc.2013-1594","article-title":"Reduced insulin sensitivity in adults with pseudohypoparathyroidism type 1a","volume":"98","author":"Muniyappa","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408268102"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1458"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0681"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2007.03.013"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.05.004"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1113"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1700"},{"issue":"2\u20133","key":"B11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1054\/npep.2002.0890","article-title":"The melanocortin receptors: lessons from knockout models","volume":"36","author":"Butler","year":"2002","journal-title":"Neuropeptides"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.035"},{"issue":"1","key":"B13","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1152\/ajpregu.00498.2006","article-title":"The dorsomedial hypothalamus: a new player in thermoregulation","volume":"292","author":"Dimicco","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.02.007"},{"issue":"Pt 3","key":"B15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1113\/jphysiol.2001.013302","article-title":"Tachycardia evoked by disinhibition of the dorsomedial hypothalamus in rats is mediated through medullary raphe","volume":"538","author":"Samuels","year":"2002","journal-title":"J Physiol (Lond)"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00016.2003"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02981-0"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.05.018"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10454"},{"issue":"10","key":"B20","first-page":"1298","article-title":"Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain","volume":"8","author":"Mountjoy","year":"1994","journal-title":"Mol Endocrinol"},{"issue":"9","key":"B21","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1210\/endo.141.9.7665","article-title":"The central melanocortin system can directly regulate serum insulin levels","volume":"141","author":"Fan","year":"2000","journal-title":"Endocrinology"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022050"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81865-6"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0483"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0453"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.1.101"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76348"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.04.006"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-1389"},{"issue":"3","key":"B30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/153537020422900303","article-title":"Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue","volume":"229","author":"Yasuda","year":"2004","journal-title":"Exp Biol Med (Maywood)"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/BF00270682"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1219-04.2004"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.03.013"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3223-10.2011"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2336-11.2011"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04515.x"},{"key":"B37","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2014.00014","article-title":"Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis","volume":"8","author":"Tupone","year":"2014","journal-title":"Front Neurosci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3737"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.067256"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12954"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31743"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24196"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1407843111"},{"key":"B44","article-title":"Inducible gene manipulations in serotonergic neurons","volume":"2","author":"Weber","year":"2009","journal-title":"Front Mol Neurosci"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/88622\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:09:57Z","timestamp":1691082597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/88622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2,1]]}},"alternative-id":["10.1172\/JCI88622"],"URL":"https:\/\/doi.org\/10.1172\/jci88622","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,19]]}}}