{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:28:59Z","timestamp":1790778539145,"version":"4.1.0"},"reference-count":87,"publisher":"American Society for Clinical Investigation","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,23]]},"DOI":"10.1172\/jci89519","type":"journal-article","created":{"date-parts":[[2017,1,22]],"date-time":"2017-01-22T23:00:29Z","timestamp":1485126029000},"page":"709-719","source":"Crossref","is-referenced-by-count":116,"title":["Kisspeptin modulates sexual and emotional brain processing in humans"],"prefix":"10.1172","volume":"127","author":[{"given":"Alexander N.","family":"Comninos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lysia","family":"Demetriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar J.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakunthala","family":"Narayanaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nesbitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chioma","family":"Izzi-Engbeaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia K.","family":"Prague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Abbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Risheka","family":"Ratnasabapathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurjinder M.","family":"Nijher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Channa N.","family":"Jayasena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Tanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrish","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenii A.","family":"Rabiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"H\u00f6nigsperger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meire Ribeiro","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Kristian","family":"Brandtzaeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Lundanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Ray","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel C.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waljit S.","family":"Dhillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2010"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1159\/000356903"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008334"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00009-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0552"},{"key":"B6","doi-asserted-by":"crossref","unstructured":"Pineda R, Plaisier F, Millar RP, Ludwig M. Amygdala kisspeptin neurons: Putative mediators of olfactory control of the gonadotropic axis [published online April 8, 2016]. Neuroendocrinology. https:\/\/doi.org\/10.1159\/000445895","DOI":"10.1159\/000445895"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2009.01892.x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1498"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102743200"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104847200"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-3046"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1408"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02322.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nn1208"},{"issue":"Pt 5","key":"B15","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/brain\/awf108","article-title":"Brain activation and sexual arousal in healthy, heterosexual males","volume":"125","author":"Arnow","year":"2002","journal-title":"Brain"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.93"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsq092"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nn1327"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsu016"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp028"},{"issue":"27","key":"B21","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1523\/JNEUROSCI.23-27-09185.2003","article-title":"Brain activation during human male ejaculation","volume":"23","author":"Holstege","year":"2003","journal-title":"J Neurosci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsu024"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00408-7"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06241.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.03.025"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2013.08.003"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018733420467"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0193(200011)11:3<162::AID-HBM30>3.0.CO;2-A"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2016.01.008"},{"key":"B30","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2016.00121","article-title":"A \u201cTimed\u201d Kiss is essential for reproduction: Lessons from mammalian studies","volume":"7","author":"Putteeraj","year":"2016","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"4","key":"B31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1155\/1999\/180434","article-title":"Differential contribution of right and left amygdala to affective information processing","volume":"11","author":"Markowitsch","year":"1998","journal-title":"Behav Neurol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/86110"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.02.004"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.67.2.319"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022119414440"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0350-06.2006"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066940"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2003.11.003"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.7.1218"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.09.038"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.2001.1691"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00838.2004"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088436"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2008.11.003"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2012.08.017"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2004.11.014"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12512"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07239.x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1512243112"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0231"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1953"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021235"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75730"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1569"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0089"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12103"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1911"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1487"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1228"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1573"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65928"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2099-07.2007"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63937"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsp052"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.02.005"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.09.010"},{"issue":"3","key":"B67","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrn3679","article-title":"On the other hand: including left-handers in cognitive neuroscience and neurogenetics","volume":"15","author":"Willems","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00078-8"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0520051"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2014.05.001"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01350.x"},{"issue":"1\u20132","key":"B72","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(95)00029-P","article-title":"Neurochemical correlates of sexual exhaustion and recovery as assessed by in vivo microdialysis","volume":"675","author":"Mas","year":"1995","journal-title":"Brain Res"},{"key":"B73","doi-asserted-by":"crossref","DOI":"10.1038\/srep31693","article-title":"Proteomics tools reveal startlingly high amounts of oxytocin in plasma and serum","volume":"6","author":"Brandtzaeg","year":"2016","journal-title":"Sci Rep"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314190110"},{"issue":"3 Pt 1","key":"B76","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.2466\/pr0.1996.79.3.1059","article-title":"Content validity of the Psychiatric Symptom Index, CES-depression Scale, and State-Trait Anxiety Inventory from the perspective of DSM-IV","volume":"79","author":"Okun","year":"1996","journal-title":"Psychol Rep"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1080\/00926239608414655"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-1971(86)80043-4"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.50.2.392"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1037\/0022-3514.54.6.1063"},{"issue":"5","key":"B81","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1743-6109.2006.00293.x","article-title":"The Sexual Arousal and Desire Inventory (SADI): a multidimensional scale to assess subjective sexual arousal and desire","volume":"3","author":"Toledano","year":"2006","journal-title":"J Sex Med"},{"key":"B82"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1080\/02699930701626582"},{"key":"B84","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2202-8-91","article-title":"Fast reproducible identification and large-scale databasing of individual functional cognitive networks","volume":"8","author":"Pinel","year":"2007","journal-title":"BMC Neurosci"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-016-1510-0"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2545-y"},{"key":"B87","doi-asserted-by":"crossref","DOI":"10.1186\/s40101-016-0089-3","article-title":"Neural substrates of sexual arousal in heterosexual males: event-related fMRI investigation","volume":"35","author":"Seok","year":"2016","journal-title":"J Physiol Anthropol"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/89519\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:10:35Z","timestamp":1691082635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/89519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":87,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2,1]]}},"alternative-id":["10.1172\/JCI89519"],"URL":"https:\/\/doi.org\/10.1172\/jci89519","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]}}}