{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:48:44Z","timestamp":1790459324589,"version":"4.1.0"},"reference-count":72,"publisher":"American Society for Clinical Investigation","issue":"1","funder":[{"name":"Sindey Kimmel Foundation","award":["SKF-13-123"],"award-info":[{"award-number":["SKF-13-123"]}]},{"DOI":"10.13039\/100000005","name":"Department of Defense","doi-asserted-by":"crossref","award":["W81XWH-13-0107"],"award-info":[{"award-number":["W81XWH-13-0107"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Worcester Research Foundation","award":["P60016170000122"],"award-info":[{"award-number":["P60016170000122"]}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"crossref","award":["NIH R01 AR063850"],"award-info":[{"award-number":["NIH R01 AR063850"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,4]]},"DOI":"10.1172\/jci92513","type":"journal-article","created":{"date-parts":[[2017,12,3]],"date-time":"2017-12-03T23:00:29Z","timestamp":1512342029000},"page":"294-308","source":"Crossref","is-referenced-by-count":70,"title":["Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma"],"prefix":"10.1172","volume":"128","author":[{"given":"Arvind M.","family":"Venkatesan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec K.","family":"Gramann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-4352","authenticated-orcid":false,"given":"Karen","family":"Dresser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharvari","family":"Gujja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchita","family":"Bhatnagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9626-1034","authenticated-orcid":false,"given":"Sagar","family":"Chhangawala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla Borges Ferreira","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin Simon","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine G.","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yariv","family":"Houvras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne J. K.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3017-3298","authenticated-orcid":false,"given":"Michael","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig J.","family":"Ceol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09454"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408868"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5256.1734"},{"issue":"6","key":"B6","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv414","article-title":"Immunotherapy Combined or Sequenced With Targeted Therapy in the Treatment of Solid Tumors: Current Perspectives","volume":"108","author":"Atkins","year":"2016","journal-title":"J Natl Cancer Inst"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412082"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611299"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105358"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412690"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.41.6750"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.024"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.12.001"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2008.73.041"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24226"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2108"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/ng1634"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201862"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature09882"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000046"},{"key":"B21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0091-679X(08)61898-1","article-title":"The zebrafish genome","volume":"60","author":"Postlethwait","year":"1999","journal-title":"Methods Cell Biol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nature08822"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.01.031"},{"key":"B24","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-11-189","article-title":"JISTIC: identification of significant targets in cancer","volume":"11","author":"Sanchez-Garcia","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r113"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200310000-00007"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1535"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nature09806"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(96)00641-7"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4773(94)00320-M"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1242\/dev.098707"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad2197"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803202106"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1121"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12256"},{"issue":"6","key":"B36","article-title":"DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer","volume":"9","author":"Hao","year":"2014","journal-title":"PLoS ONE"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.07.032"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1021\/cb9002865"},{"key":"B39","doi-asserted-by":"crossref","DOI":"10.1038\/srep07596","article-title":"Smad9 is a new type of transcriptional regulator in bone morphogenetic protein signaling","volume":"4","author":"Tsukamoto","year":"2014","journal-title":"Sci Rep"},{"issue":"7","key":"B40","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nrm2428","article-title":"A gene regulatory network orchestrates neural crest formation","volume":"9","author":"Sauka-Spengler","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00757.x"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0298"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1350705"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds560"},{"key":"B45","doi-asserted-by":"crossref","DOI":"10.1186\/1471-213X-6-43","article-title":"Eye and neural defects associated with loss of GDF6","volume":"6","author":"Hanel","year":"2006","journal-title":"BMC Dev Biol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-11315"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004877"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002265"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00808"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.17.7559-7566.2004"},{"issue":"2","key":"B51","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/0008-5472.448.65.2","article-title":"Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration","volume":"65","author":"Rothhammer","year":"2005","journal-title":"Cancer Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210182"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01301.x"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2008.55"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.115"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1101\/gad.406406"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.641"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00026-X"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp008"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036789"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00022-2"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0222"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/ng1916"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2772"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.04.030"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.044"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/nature06251"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406252102"},{"issue":"17","key":"B70","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1242\/dev.126.17.3757","article-title":"nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate","volume":"126","author":"Lister","year":"1999","journal-title":"Development"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204962200"},{"issue":"Web Server issue","key":"B72","doi-asserted-by":"crossref","first-page":"W77","DOI":"10.1093\/nar\/gkt439","article-title":"WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013","volume":"41","author":"Wang","year":"2013","journal-title":"Nucleic Acids Res"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/92513\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:21:58Z","timestamp":1693326118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/92513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1,2]]}},"alternative-id":["10.1172\/JCI92513"],"URL":"https:\/\/doi.org\/10.1172\/jci92513","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]}}}