{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:01:08Z","timestamp":1790632868361,"version":"4.1.0"},"reference-count":56,"publisher":"American Society for Clinical Investigation","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,24]]},"DOI":"10.1172\/jci92885","type":"journal-article","created":{"date-parts":[[2017,7,23]],"date-time":"2017-07-23T18:00:32Z","timestamp":1500832832000},"page":"3167-3176","source":"Crossref","is-referenced-by-count":92,"title":["Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males"],"prefix":"10.1172","volume":"127","author":[{"given":"Simona","family":"Pace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Pergola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Dehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Gerstmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Troisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Pein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja M.","family":"Schaible","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Weinigel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Rummler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinnak","family":"Northoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Laufer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten J.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olof","family":"R\u00e5dmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Samuelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6269-5088","authenticated-orcid":false,"given":"Andreas","family":"Koeberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Sautebin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Werz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071371"},{"issue":"4","key":"B2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbalip.2014.08.012","article-title":"5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease","volume":"1851","author":"R\u00e5dmark","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E12-06-0489"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/343282a0"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1144346"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808211106"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-278010"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ni0901-777"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.7.587"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78082"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809120105"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-182758"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.05.011"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.000901"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.3.433"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI89429"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-198036"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.04.090"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12114"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/465688a"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2006.11.001"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2014.922866"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76262"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012203232505"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1139\/y89-073"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.6.1905"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.6.1065"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2013.06.004"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.07.009"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1021\/jm900212y"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90382-7"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0206-0"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707416"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.4.1347"},{"issue":"Suppl 1","key":"B35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000070474","article-title":"The roles of cysteinyl leukotrienes in eosinophilic inflammation of asthmatic airways","volume":"131","author":"Nagata","year":"2003","journal-title":"Int Arch Allergy Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth947"},{"key":"B37","first-page":"123","article-title":"Pleural models of inflammation: immune and nonimmune","volume":"225","author":"Moore","year":"2003","journal-title":"Methods Mol Biol"},{"issue":"3","key":"B38","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0022-3565(25)38889-0","article-title":"In vivo characterization of zymosan-induced mouse peritoneal inflammation","volume":"269","author":"Rao","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"B39","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11350","article-title":"Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator","volume":"7","author":"Zhu","year":"2016","journal-title":"Nat Commun"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100333"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-3317"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(93)90096-F"},{"issue":"3","key":"B43","first-page":"583","article-title":"BAY x 1005 attenuates atherosclerosis in apoE\/LDLR - double knockout mice","volume":"58","author":"Jawie\u0144","year":"2007","journal-title":"J Physiol Pharmacol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2006.01606.x"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.158089"},{"issue":"1\u20133","key":"B46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejphar.2010.05.003","article-title":"Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation","volume":"640","author":"Lorrain","year":"2010","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"B47","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/S0021-9258(19)40034-3","article-title":"MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes","volume":"265","author":"Rouzer","year":"1990","journal-title":"J Biol Chem"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1410983111"},{"key":"B49","article-title":"MK-886, an effective oral leukotriene biosynthesis inhibitor on antigen-induced early and late asthmatic reactions in man","volume":"141","author":"Bel","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1136\/thx.52.4.342"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.1.289"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1086\/428066"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/ng1311"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.18.2245"},{"issue":"12","key":"B55","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/jama.1996.03530360041036","article-title":"Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group","volume":"275","author":"Israel","year":"1996","journal-title":"JAMA"},{"issue":"5 Pt 1","key":"B56","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0091-6749(96)80002-9","article-title":"Acute and chronic effects of a 5-lipoxygenase inhibitor in asthma: a 6-month randomized multicenter trial. Zileuton Study Group","volume":"98","author":"Liu","year":"1996","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/92885\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T13:28:04Z","timestamp":1750771684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/92885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,24]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8,1]]}},"alternative-id":["10.1172\/JCI92885"],"URL":"https:\/\/doi.org\/10.1172\/jci92885","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,24]]}}}