{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T22:57:38Z","timestamp":1776293858435,"version":"3.50.1"},"reference-count":85,"publisher":"American Society for Clinical Investigation","issue":"9","funder":[{"name":"the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT)","award":["the Leading Project for Realization of Regenerative Medicine from MEXT"],"award-info":[{"award-number":["the Leading Project for Realization of Regenerative Medicine from MEXT"]}]},{"name":"the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT)","award":["the Leading Project for Realization of Regenerative Medicine from MEXT"],"award-info":[{"award-number":["the Leading Project for Realization of Regenerative Medicine from MEXT"]}]},{"name":"Japan Society for the Promotion of Science (JSPS)","award":["Grants-in-aid for Scientific Research from JSPS (25293320"],"award-info":[{"award-number":["Grants-in-aid for Scientific Research from JSPS (25293320"]}]},{"name":"Japan Society for the Promotion of Science (JSPS)","award":["#16K15662 )"],"award-info":[{"award-number":["#16K15662 )"]}]},{"name":"Japan Society for the Promotion of Science (JSPS)","award":["Grants-in-aid for Scientific Research from JSPS (25293320"],"award-info":[{"award-number":["Grants-in-aid for Scientific Research from JSPS (25293320"]}]},{"name":"Japan Society for the Promotion of Science (JSPS)","award":["#16K15662 )"],"award-info":[{"award-number":["#16K15662 )"]}]},{"name":"Japan Science and Technology Agency (JST) and Japan Agency for Medical Research and development (AMED)","award":["the Program for Intractable Diseases Research utilizing Disease-specific iPS cells from JST"],"award-info":[{"award-number":["the Program for Intractable Diseases Research utilizing Disease-specific iPS cells from JST"]}]},{"name":"Japan Science and Technology Agency (JST) and Japan Agency for Medical Research and development (AMED)","award":["Japan Agency for Medical Research"],"award-info":[{"award-number":["Japan Agency for Medical Research"]}]},{"name":"Japan Science and Technology Agency (JST) and Japan Agency for Medical Research and development (AMED)","award":["development (AMED)"],"award-info":[{"award-number":["development (AMED)"]}]},{"name":"Japan Science and Technology Agency (JST) and Japan Agency for Medical Research and development (AMED)","award":["the Program for Intractable Diseases Research utilizing Disease-specific iPS cells from JST"],"award-info":[{"award-number":["the Program for Intractable Diseases Research utilizing Disease-specific iPS cells from JST"]}]},{"name":"Japan Science and Technology Agency (JST) and Japan Agency for Medical Research and development (AMED)","award":["Japan Agency for Medical Research"],"award-info":[{"award-number":["Japan Agency for Medical Research"]}]},{"name":"Japan Science and Technology Agency (JST) and Japan Agency for Medical Research and development (AMED)","award":["development (AMED)"],"award-info":[{"award-number":["development (AMED)"]}]},{"name":"Japan Agency for Medical Research and development (AMED)","award":["Core Center for iPS Cell Research of the Research Center Network for Realization of Regenerative Medicine from AMED"],"award-info":[{"award-number":["Core Center for iPS Cell Research of the Research Center Network for Realization of Regenerative Medicine from AMED"]}]},{"name":"Japan Agency for Medical Research and development (AMED)","award":["Core Center for iPS Cell Research of the Research Center Network for Realization of Regenerative Medicine from AMED"],"award-info":[{"award-number":["Core Center for iPS Cell Research of the Research Center Network for Realization of Regenerative Medicine from AMED"]}]},{"name":"Japan Agency for Medical Research and development (AMED)","award":["the Research on Development of New Drugs from AMED"],"award-info":[{"award-number":["the Research on Development of New Drugs from AMED"]}]},{"name":"Japan Agency for Medical Research and development (AMED)","award":["the Research on Development of New Drugs from AMED"],"award-info":[{"award-number":["the Research on Development of New Drugs from AMED"]}]},{"name":"Center for iPS Cell Research and Application, Kyoto University (CiRA)","award":["iPS Cell Research Fund"],"award-info":[{"award-number":["iPS Cell Research Fund"]}]},{"name":"Center for iPS Cell Research and Application, Kyoto University (CiRA)","award":["iPS Cell Research Fund"],"award-info":[{"award-number":["iPS Cell Research Fund"]}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency (JST)","doi-asserted-by":"crossref","award":["A-STEP (Adaptable"],"award-info":[{"award-number":["A-STEP (Adaptable"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency (JST)","doi-asserted-by":"crossref","award":["Seamless Technology Transfer Program through target-driven R&D"],"award-info":[{"award-number":["Seamless Technology Transfer Program through target-driven R&D"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency (JST)","doi-asserted-by":"crossref","award":["Exploratory Research) from JST (AS242Z00931P)"],"award-info":[{"award-number":["Exploratory Research) from JST (AS242Z00931P)"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency (JST)","doi-asserted-by":"crossref","award":["A-STEP (Adaptable"],"award-info":[{"award-number":["A-STEP (Adaptable"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency (JST)","doi-asserted-by":"crossref","award":["Seamless Technology Transfer Program through target-driven R&D"],"award-info":[{"award-number":["Seamless Technology Transfer Program through target-driven R&D"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency (JST)","doi-asserted-by":"crossref","award":["Exploratory Research) from JST (AS242Z00931P)"],"award-info":[{"award-number":["Exploratory Research) from JST (AS242Z00931P)"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Japan Agency for Medical Research and development (AMED)","award":["the Practical Research Project for Rare\/Intractable Diseases from AMED"],"award-info":[{"award-number":["the Practical Research Project for Rare\/Intractable Diseases from AMED"]}]},{"name":"Japan Agency for Medical Research and development (AMED)","award":["the Practical Research Project for Rare\/Intractable Diseases from AMED"],"award-info":[{"award-number":["the Practical Research Project for Rare\/Intractable Diseases from AMED"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,31]]},"DOI":"10.1172\/jci93521","type":"journal-article","created":{"date-parts":[[2017,7,30]],"date-time":"2017-07-30T22:00:26Z","timestamp":1501452026000},"page":"3339-3352","source":"Crossref","is-referenced-by-count":157,"title":["Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva"],"prefix":"10.1172","volume":"127","author":[{"given":"Kyosuke","family":"Hino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Horigome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shingo","family":"Komura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanae","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengzhu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-4310","authenticated-orcid":false,"given":"Akira","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Toguchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3930-8032","authenticated-orcid":false,"given":"Makoto","family":"Ikeya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1385\/BMM:3:3-4:183"},{"issue":"346","key":"B2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1385\/BMM:3:3-4:201","article-title":"The genetics of fibrodysplasia ossificans progressiva","volume":"3","author":"Shore","year":"2005","journal-title":"Clinic Rev Bone Miner Metab"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1402.039"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2007.11.007"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.122"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010280"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34174"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ng1783"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3698.893"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.13.1580"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.3201241"},{"issue":"11","key":"B12","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1242\/dev.126.11.2551","article-title":"The type I serine\/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo","volume":"126","author":"Gu","year":"1999","journal-title":"Development"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9378"},{"issue":"15","key":"B14","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1096\/fasebj.13.15.2105","article-title":"Specificity, diversity, and regulation in TGF-beta superfamily signaling","volume":"13","author":"Piek","year":"1999","journal-title":"FASEB J"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00121-5"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0023"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp148"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.02.043"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.10.093"},{"issue":"3","key":"B20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1359\/jbmr.071030","article-title":"Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva (FOP)","volume":"23","author":"Billings","year":"2008","journal-title":"J Bone Miner Res"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.365932"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1888"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1021\/cb9002865"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1221"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.03.113"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1021\/cb300655w"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062721"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2334"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.152"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.193"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515397113"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2848"},{"key":"B33","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-8-163","article-title":"Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial","volume":"8","author":"Kitoh","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.023929"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.02.008"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.06.014"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2820"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1510540112"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4358"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408090200"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0290"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.114959"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112291"},{"key":"B44","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-8-190","article-title":"Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation","volume":"8","author":"Matsumoto","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1981"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.28.721"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3531"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73937"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00695-08"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1637"},{"key":"B51","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2210-9-8","article-title":"Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models","volume":"9","author":"Lee","year":"2009","journal-title":"BMC Pharmacol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3000"},{"issue":"12","key":"B53","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrd3577","article-title":"Induced pluripotent stem cells--opportunities for disease modelling and drug discovery","volume":"10","author":"Grskovic","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.05.016"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2672"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.017"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/nature11861"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3757"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.004"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00039.2010"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.08.002"},{"issue":"7505","key":"B62","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nature13255","article-title":"mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert)","volume":"510","author":"Rodgers","year":"2014","journal-title":"Nature"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3591"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.04.003"},{"issue":"Pt 17","key":"B65","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1242\/jcs.094789","article-title":"The bright and the dark sides of activin in wound healing and cancer","volume":"125","author":"Antsiferova","year":"2012","journal-title":"J Cell Sci"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.32"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2515"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf1090"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80067-2"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-252783"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1242\/dev.108811"},{"key":"B72","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11151","article-title":"mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation","volume":"7","author":"Yan","year":"2016","journal-title":"Nat Commun"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.12.013"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nri2546"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/nri3901"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1242\/dev.066498"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2014.104"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.166.2.895"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1177\/108705719900400206"},{"key":"B80","doi-asserted-by":"crossref","DOI":"10.1038\/srep00455","article-title":"Human chondrogenic paraxial mesoderm, directed specification and prospective isolation from pluripotent stem cells","volume":"2","author":"Umeda","year":"2012","journal-title":"Sci Rep"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053771"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20180"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63572"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.005"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.01.016"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/93521\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:12:34Z","timestamp":1691082754000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/93521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,31]]},"references-count":85,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9,1]]}},"alternative-id":["10.1172\/JCI93521"],"URL":"https:\/\/doi.org\/10.1172\/jci93521","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,31]]}}}