{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:39:20Z","timestamp":1783575560943,"version":"3.55.0"},"reference-count":58,"publisher":"American Society for Clinical Investigation","issue":"12","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DK076683"],"award-info":[{"award-number":["DK076683"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,23]]},"DOI":"10.1172\/jci94138","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T15:38:55Z","timestamp":1508773135000},"page":"4257-4269","source":"Crossref","is-referenced-by-count":53,"title":["Advillin acts upstream of phospholipase C \u03f51 in steroid-resistant nephrotic syndrome"],"prefix":"10.1172","volume":"127","author":[{"given":"Jia","family":"Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazia","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie T.","family":"van der Ven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8741-6177","authenticated-orcid":false,"given":"Heon Yung","family":"Gee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela A.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Feh\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep P.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Esmaeilniakooshkghazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Il","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-6783","authenticated-orcid":false,"given":"Tilman","family":"Jobst-Schwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna Magdalena","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7773-5190","authenticated-orcid":false,"given":"Eugen","family":"Widmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian K.","family":"Warejko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0441-7749","authenticated-orcid":false,"given":"Tobias","family":"Hermle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svjetlana","family":"Lovric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirlee","family":"Shril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankana","family":"Daga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Nayir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yincent","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Helmchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevgi","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5627-6100","authenticated-orcid":false,"given":"Afig","family":"Berdeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameela A.","family":"Kari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"El Desoky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8942-1973","authenticated-orcid":false,"given":"Neveen A.","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Bagga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikant","family":"Mane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad A.","family":"Jairajpuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Lifton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Khurana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedhelm","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002222"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra052131"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60236-X"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/74139"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv355"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.148"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2009.08.012"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69134"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1367-y"},{"key":"B10","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10822","article-title":"FAT1 mutations cause a glomerulotubular nephropathy","volume":"7","author":"Gee","year":"2016","journal-title":"Nat Commun"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3512"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79504"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050489"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000353"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/ng.662"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2012-100973"},{"key":"B17","first-page":"43","article-title":"Diffuse mesangial sclerosis: a congenital glomerulopathy with nephrotic syndrome","volume":"22","author":"Habib","year":"1993","journal-title":"Adv Nephrol Necker Hosp"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.693"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/ng1918"},{"issue":"Pt 15","key":"B20","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1242\/jcs.111.15.2129","article-title":"Advillin (p92): a new member of the gelsolin\/villin family of actin regulatory proteins","volume":"111","author":"Marks","year":"1998","journal-title":"J Cell Sci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03518104"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.4.1109"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E04-05-0431"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2026"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.08.013"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008324200"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nature08231"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69000"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014121197"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.11.018"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1981.209"},{"issue":"6","key":"B32","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: a unified multipoint approach","volume":"58","author":"Kruglyak","year":"1996","journal-title":"Am J Hum Genet"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1086\/302911"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/ng1786"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nature10814"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1818"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq662"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btm404"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1626"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2011.09.006"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1021\/ct400314y"},{"issue":"8","key":"B43","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/prot.22711","article-title":"Improved side-chain torsion potentials for the Amber ff99SB protein force field","volume":"78","author":"Lindorff-Larsen","year":"2010","journal-title":"Proteins"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1021\/ja00036a015"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1021\/jp401587e"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1021\/ja012750u"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1021\/ct400341p"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"issue":"3","key":"B51","doi-asserted-by":"crossref","first-page":"C1046","DOI":"10.1152\/ajpcell.2001.281.3.C1046","article-title":"Regulation of phospholipase C-gamma(1) by the actin-regulatory protein villin","volume":"281","author":"Panebra","year":"2001","journal-title":"Am J Physiol, Cell Physiol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308878200"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703617200"},{"issue":"3","key":"B54","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1681\/ASN.V133630","article-title":"A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression","volume":"13","author":"Saleem","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.06.007"},{"issue":"2","key":"B56","doi-asserted-by":"crossref","DOI":"10.23937\/2469-570X\/1410014","article-title":"Sphingosine 1-phosphate receptor 2 regulates the migration, proliferation, and differentiation of mesenchymal stem cells","volume":"2","author":"Price","year":"2015","journal-title":"Int J Stem Cell Res Ther"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)01131-2"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600280"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/94138\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T17:12:58Z","timestamp":1691082778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/94138"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,23]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,10,23]]}},"alternative-id":["10.1172\/JCI94138"],"URL":"https:\/\/doi.org\/10.1172\/jci94138","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,23]]}}}