{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:48:37Z","timestamp":1790707717948,"version":"4.1.0"},"reference-count":83,"publisher":"American Society for Clinical Investigation","issue":"5","funder":[{"name":"Ministry of Science and Technology of the People\u2019s Republic of China","award":["National Key Research"],"award-info":[{"award-number":["National Key Research"]}]},{"name":"Ministry of Science and Technology of the People\u2019s Republic of China","award":["Development Program of China (Grant No. 2017YFC1308900)"],"award-info":[{"award-number":["Development Program of China (Grant No. 2017YFC1308900)"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No. 81672367"],"award-info":[{"award-number":["Grant No. 81672367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["(Grant No. 81572329"],"award-info":[{"award-number":["(Grant No. 81572329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["(Grant No. 81572601"],"award-info":[{"award-number":["(Grant No. 81572601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Agency of Jiangsu Province, China","award":["The Key Research"],"award-info":[{"award-number":["The Key Research"]}]},{"name":"Science and Technology Agency of Jiangsu Province, China","award":["Development Program of Jiangsu Province (No. BE2017607)"],"award-info":[{"award-number":["Development Program of Jiangsu Province (No. BE2017607)"]}]},{"name":"Ministry of Science and Technology of the People\u2019s Republic of China","award":["the National Major Projects for \u201cMajor New Drugs Innovation"],"award-info":[{"award-number":["the National Major Projects for \u201cMajor New Drugs Innovation"]}]},{"name":"Ministry of Science and Technology of the People\u2019s Republic of China","award":["Development\u201d (Grant No.2018ZX09301048-003)"],"award-info":[{"award-number":["Development\u201d (Grant No.2018ZX09301048-003)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,8]]},"DOI":"10.1172\/jci99538","type":"journal-article","created":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T12:09:29Z","timestamp":1551787769000},"page":"2056-2070","source":"Crossref","is-referenced-by-count":219,"title":["Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors"],"prefix":"10.1172","volume":"129","author":[{"given":"Fangjun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyun","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanyan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiqing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1090-3065","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyao","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baorui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"232","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.116"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0116"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)70054-9"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nature13904"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0105"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)00175-3"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500596"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0040-8"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3161"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nature13988"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1348"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0095"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.11.002"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202830"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nature14426"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251102"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0433"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2010.141"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nature13387"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609279"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84940"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235122"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.247"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3773"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nature18945"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad1253"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0264"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1065369"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1219825"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-2023"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2696"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0184"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.231100"},{"issue":"3","key":"B34","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv332","article-title":"Prospective clinical study of precision oncology in solid tumors","volume":"108","author":"Sohal","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0333-9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0143"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00100F"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2016.12.003"},{"key":"B39","article-title":"Liquid biopsy in non-small cell lung cancer","volume":"3","author":"Molina-Vila","year":"2016","journal-title":"Front Med (Lausanne)"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1231"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.0494"},{"issue":"Database issue","key":"B42","doi-asserted-by":"crossref","first-page":"D784","DOI":"10.1093\/nar\/gku1166","article-title":"Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations","volume":"43","author":"Gonz\u00e1lez-Galarza","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/nature22991"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.012"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-006-0225-8"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1177\/0300060514561504"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0229"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-013-1407-9"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.09.014"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052494"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.5.3099"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2016.05.002"},{"issue":"28","key":"B53","doi-asserted-by":"crossref","first-page":"43039","DOI":"10.18632\/oncotarget.9915","article-title":"Combination of radiotherapy and vaccination overcomes checkpoint blockade resistance","volume":"7","author":"Zheng","year":"2016","journal-title":"Oncotarget"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/nature23003"},{"key":"B55","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2013.00028","article-title":"Mechanisms and insights into drug resistance in cancer","volume":"4","author":"Zahreddine","year":"2013","journal-title":"Front Pharmacol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1249558"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/nature10755"},{"issue":"38","key":"B58","doi-asserted-by":"crossref","first-page":"61755","DOI":"10.18632\/oncotarget.11237","article-title":"Mutational profiling of non-small-cell lung cancer patients resistant to first-generation EGFR tyrosine kinase inhibitors using next generation sequencing","volume":"7","author":"Jin","year":"2016","journal-title":"Oncotarget"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp324"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/ng.806"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1101\/gr.129684.111"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu549"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1110\/ps.0239403"},{"issue":"Web Server issue","key":"B65","doi-asserted-by":"crossref","first-page":"W509","DOI":"10.1093\/nar\/gkn202","article-title":"NetMHC-3.0: accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11","volume":"36","author":"Lundegaard","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv639"},{"issue":"1","key":"B67","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13073-016-0288-x","article-title":"NetMHCpan-3.0; improved prediction of binding to MHC class I molecules integrating information from multiple receptor and peptide length datasets","volume":"8","author":"Nielsen","year":"2016","journal-title":"Genome Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-008-0341-z"},{"key":"B69","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-10-296","article-title":"NN-align. An artificial neural network-based alignment algorithm for MHC class II peptide binding prediction","volume":"10","author":"Nielsen","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"B70","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-8-238","article-title":"Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method","volume":"8","author":"Nielsen","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2764"},{"issue":"Database issue","key":"B72","doi-asserted-by":"crossref","first-page":"D805","DOI":"10.1093\/nar\/gku1075","article-title":"COSMIC: exploring the world\u2019s knowledge of somatic mutations in human cancer","volume":"43","author":"Forbes","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2015.11.006"},{"issue":"269","key":"B74","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004088","article-title":"Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal","volume":"6","author":"Gao","year":"2013","journal-title":"Sci Signal"},{"issue":"1","key":"B75","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4049\/jimmunol.152.1.163","article-title":"Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains","volume":"152","author":"Parker","year":"1994","journal-title":"J Immunol"},{"key":"B76","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-8-424","article-title":"Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction","volume":"8","author":"Larsen","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050595"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-002-0273-7"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-012-1379-1"},{"key":"B80","article-title":"CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients","volume":"6","author":"Su","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"B81","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00262-006-0195-x","article-title":"An altered peptide ligand for na\u00efve cytotoxic T lymphocyte epitope of TRP-2(180-188) enhanced immunogenicity","volume":"56","author":"Tang","year":"2007","journal-title":"Cancer Immunol Immunother"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-010-0820-6"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1172\/JCI82416"}],"container-title":["Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jci.org\/articles\/view\/99538\/files\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T01:05:20Z","timestamp":1694653520000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jci.org\/articles\/view\/99538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":83,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5,1]]},"published-print":{"date-parts":[[2019,5,1]]}},"alternative-id":["10.1172\/JCI99538"],"URL":"https:\/\/doi.org\/10.1172\/jci99538","relation":{},"ISSN":["0021-9738","1558-8238"],"issn-type":[{"value":"0021-9738","type":"print"},{"value":"1558-8238","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,8]]}}}