{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T06:56:57Z","timestamp":1747810617863},"reference-count":46,"publisher":"American Psychiatric Association Publishing","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[1947,1]]},"DOI":"10.1176\/ajp.103.4.524","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T18:02:15Z","timestamp":1418839335000},"page":"524-527","source":"Crossref","is-referenced-by-count":3,"title":["NEUROSYPHILIS"],"prefix":"10.1176","volume":"103","author":[{"given":"AUGUSTUS S.","family":"ROSE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HARRY C.","family":"SOLOMON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"230","reference":[{"volume-title":"Epilepsieer bij Kinderen. Paper, 140","author":"Ledeboer B.","key":"p_1"},{"volume-title":"Bologna","year":"1946","author":"Moruzzi","key":"p_2"},{"key":"p_3","volume-title":"Science and seizures","author":"Lennox W. G.","year":"1946","edition":"2"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)35998-3"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(46)80150-1"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.103.2.159"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.103.2.154"},{"key":"p_8","first-page":"2","volume":"5","author":"Swinyard E. A.","year":"1946","journal-title":"Fed. Proc."},{"volume-title":"Sept.","year":"1946","author":"Goodman L. S.","key":"p_9"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(46)80238-5"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1946.02870090019006"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.103.2.162"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1946.02870360046021"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1946.02870360013003"},{"volume-title":"Sept.","year":"1946","author":"Mackay R. P.","key":"p_16"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1945.tb00669.x"},{"key":"p_19","first-page":"105","volume":"5","author":"Toman J. E. P.","year":"1946","journal-title":"Fed. 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Nursing"},{"key":"p_33","unstructured":"The literature on neurosyphilis in 1946 was year, not dealing with penicillin, which deagain dominated by the subject of penicillin therapy. Another year not only added more cases to the investigative studies but also, by virtue of the time elapsed, added validity to treatment results. All observers are in agreement as to the effect of penicillin on the spinal fluid abnormalities but a healthy, stimulating difference of opinion apparently exists concerning the need for fever therapy. There were also several papers during the serve comment."},{"key":"p_34","unstructured":"Many of those interested in the historical aspects of fever therapy will recall their disturbed feelings on reading the publication of Zakon and Neymann( i) in 1943, and subsequently, the editorial in the Journal of the American Medical Association of April 8, i, in which it was stated that priority for the use of malaria and relapsing fever in the treatment of general paralysis should belong to Rosenblum. Although the importance of Dr. Julius Wagner-Jauregg's work was in no-wise belittled by these publications, it is consoling to the admirers of Wagner-Jauregg to have his version of this subject put into print. \"The History of the Malaria Treatment of General Paralysis\" by Wagner-Jauregg, translated from the German by Bruetsch(2), recognized Rosenblum but points out that he did not follow up by further investigation his observations psychoses recover with fever. that some"},{"key":"p_37","unstructured":"Two interesting and instructive cases of syphilitic arachnoiditis treated by penicillin were reported by Callaway and his coworkers(6). The first case was operated upon and thickened spinal arachnoid was removed for pathological examination. Symptomatic improvement followed surgery and penicillin therapy, although spinal fluid relapse subsequently necessitated fever therapy and a repeat course of penicillin. The second case showed a neurological picture of upper thoracic spinal cord compression with partial subarachnoid block. Gradual disappearance of neurological signs followed treatment with penicillin. Since surgical. exploration was not necessary in the second case, a differential diagnosis between arachnoiditis and pachymeningitis was not established but there is no doubt of the syphilitic etiology in either case."},{"volume-title":"interest was stirred into the possibility of intrathecal injection of the drug for the treatment of neurosyphilis","year":"1945","author":"Following","key":"p_38"},{"volume-title":"active","author":"Callaway","key":"p_39"},{"key":"p_40","unstructured":"O'Leary and co-workers(9) reported the treatment with penicillin of `oo patients with different types of neurosyphilis, in various schedules and doses and also in combination with fever therapy. They emphasized that the most outstanding result common to most patients is found in the spinal fluid, which showed a return of cell count, total protein and gold curve to within normal limits and a reduction of strength of the complement fixation test. The outstanding clinical efforts were a gain in weight and a reduction of severity and frequency of pains in the legs. They state further that patients who had meningeal neurosyphilis were most responsive both clinically and serologically, while patients who had parenchymatous forms of the disease were helped only slightly, if at alL O'Leary and Kierland(5) in a review of \"Today's Treatment of Syphilis\" read in the general scientific meetings at the 95th annual session of the American Medical Association, San Francisco, July 2, 1946, restated the above results and pointed out that \"more clinical remissions were obtained in paretic patients who received combined penicillinfever treatment than when penicillin was given alone. In fact, we have not observed a frank clinical remission in a paretic patient after administration of penicillin alone, although such remissions have been observed by others.\""},{"key":"p_51","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1943.01510010056009"},{"volume-title":"Walter L. The history of the malaria treatment of general paralysis. Am. J. Psychiat., 102 :577","year":"1946","author":"Wagnen-Jaunegg","key":"p_52"},{"volume-title":"Jan. 5","year":"1946","author":"Bruetsch","key":"p_53"},{"volume-title":"Dis. Ncr. Syst.","author":"Revilla G.","key":"p_54"},{"key":"p_55","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1946.02870430010004"},{"key":"p_56","first-page":"231","volume":"30","author":"Callaway J","year":"1946","journal-title":"Gonor. and Ven. Dis."},{"key":"p_57","first-page":"235","volume":"30","author":"Weickhardt D","year":"1946","journal-title":"Gonor. and Ven. Dis."},{"volume-title":"Lamar and others. The use of penicillin in the treatment of syphilis of the central Nervous system","year":"1946","author":"Callaway J.","key":"p_58"},{"issue":"698","key":"p_59","first-page":"x6","volume":"130","author":"O'Leary A.","year":"1946","journal-title":"J. A. M. A."},{"key":"p_60","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1946.02870180003001"},{"volume-title":"II. Dementia paralytica. J. A. M. A., 131 :1255","year":"1946","author":"Reynolds W.","key":"p_61"},{"volume-title":"Penicillin in the treatment of neurosyphilis","author":"Rose S.","key":"p_62","doi-asserted-by":"crossref","DOI":"10.1001\/jama.1947.02880010007002"},{"key":"p_64","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1001\/jama.1946.02870360030011","volume":"132","author":"Tucker A.","year":"1946","journal-title":"J. A. M. A."}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.103.4.524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:03:59Z","timestamp":1722384239000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.103.4.524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1947,1]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1947,1]]}},"alternative-id":["10.1176\/ajp.103.4.524"],"URL":"https:\/\/doi.org\/10.1176\/ajp.103.4.524","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"type":"print","value":"0002-953X"},{"type":"electronic","value":"1535-7228"}],"subject":[],"published":{"date-parts":[[1947,1]]}}}