{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T13:10:10Z","timestamp":1721826610077},"reference-count":37,"publisher":"American Psychiatric Association Publishing","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[1950,1]]},"DOI":"10.1176\/ajp.106.7.522","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T18:05:35Z","timestamp":1418839535000},"page":"522-524","source":"Crossref","is-referenced-by-count":0,"title":["NEUROSYPHILIS"],"prefix":"10.1176","volume":"106","author":[{"given":"AUGUSTUS S.","family":"ROSE","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"230","reference":[{"key":"p_1","first-page":"213","volume":"18","author":"Pennington A. W.","year":"1949","journal-title":"Med."},{"key":"p_2","first-page":"100","volume":"6","author":"Doll R.","year":"1949","journal-title":"Brit. J. Indust. Med."},{"key":"p_3","first-page":"6","volume":"18","author":"Solomon A. P.","year":"1949","journal-title":"Med."},{"key":"p_4","volume-title":"18: 29","author":"Csillag I.","year":"1949"},{"key":"p_5","first-page":"383","volume":"17","author":"Hanman B.","year":"1948","journal-title":"Mccl."},{"issue":"336","key":"p_6","volume":"95","author":"Rowbotham G. F","journal-title":"J. Ment. Sc."},{"key":"p_7","first-page":"344","volume":"27","author":"Moore H","year":"1949","journal-title":"Personnel J."},{"key":"p_8","volume-title":"212","author":"Redmon E. J.","year":"1949"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1038\/163221a0"},{"key":"p_11","volume-title":"i8: 133","author":"Felton J. S.","year":"1949"},{"key":"p_12","first-page":"1949","volume":"22","author":"Ahern E","journal-title":"Management News"},{"key":"p_13","volume-title":"220","author":"Bell R. G.","year":"1949"},{"key":"p_14","volume-title":"i: 268","author":"O'Brien C. C.","year":"1949"},{"key":"p_15","volume-title":"ccl","author":"Rees J. R.","year":"1949"},{"key":"p_18","unstructured":"Again in 1949, studies in neurosyphilis have placed emphasis upon the results of penicillin therapy. Insufficient time has elapsed, according to the experience of many, to accept penicillin alone as the only treatment for the late parenchymatous forms of neurosyphilis-to the exclusion of fever therapy-yet Stokes, et al. () and Dattner (2) find no reason after five years of followup of their cases to change their previous conclusions that penicillin alone is sufficient. Dattner has found that failures of penicillin therapy, based on careful examination of the spinal fluid, can be satisfactorily managed by repeated courses of penicillin by increasing the amount and duration of treatment. Curtis, et al. (3) and Curtis(4) state that the results of penicillin alone, even in taboparesis and paresis, appear equal to the results of penicillin plus malaria therapy, but as yet they are not ready to give up fever in these forms of the disease. The experience and judgments of these investigators from the University of Pennsylvania, Bellevue Hospital and University of Michigan respectively as well as the extensive experience at many other treatment centers, can be accepted as proof that penicillin, with or without fever therapy, is the best available treatment for all forms of neurosyphilis today. It is not necessary, as indicated by Johnson (5), to give chemotherapy also."},{"key":"p_20","unstructured":"Goldman(7), in a presentation before the Section on Nervous and Mental Diseases of the A. M. A., gave the results of his treatment and studies on \"140 patients whose neurosyphilis was of uniformly severe character and who were sufficiently ill to be committed to a state hospital.\" Extensive psychologic tests were performed on 36 patients, from which data he concluded that \"psychologic tests are probably of more value in following the progress of a patient with dementia paralytica than laboratory tests.\" The cases were divided into 6 groups, in numbers varying from JO to 45, to which penicillin was administered in varying amounts and techniques. All but I, cases received some penicillin intraspinally. \"The most favorable results are apparently obtained by the combination of intramuscular and intraspinal injections of salts of penicillin with fever and administration of bismuth.\" Most investigators have not found intraspinal penicillin necessary or advisable, and in their critical and exhaustive review of the literature, Tucker, et al. (8), state: \"In spite of such experimental evidence of occasional toxic sequelae to the intrathecal 19501 REVIEW OF PSYCHIATRIC #{149} administration of penicillin and the bulk of clinical evidence showing that it offers no advantage in terms of end results in the treatment of syphilis of the central nervous system over the intramuscular or intravenous routes, a few workers persist in this dangerous and unnecessary method of treatment.\""},{"key":"p_22","unstructured":"Klauder and Gross( io) presented an interim report on 56 patients with syphilitic optic atrophy treated with penicillin between April, 1944 and November, 1948. Thirtyfour cases were treated with intramuscular penicillin q. 3 h. for 74 days to a total of 4.2 million units, and 22 cases were given 6 million units penicillin in 74 days combined with malaria. Penicillin was repeated and in the first group malaria was administered visual loss progressed unfavorably."},{"key":"p_24","volume-title":"progressive","author":"Of"},{"key":"p_26","unstructured":"PROGRESS1949 523"},{"key":"p_28","volume-title":"I 5 treated with penicillin alone and i5 treated with penicillin and malaria, were reported by Packer and Wong(12)","author":"Thirty","year":"1932"},{"key":"p_31","volume-title":"Recent Advances in the Study of Venereal Diseases. A symposium. Held under auspices of the Syphilis Study Section, National Institute of Health, U. S. Public Health Service. Washington, D. C.","author":"Stokes H.","year":"1949"},{"key":"p_34","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1949.11945569"},{"issue":"451","key":"p_35","first-page":"949","volume":"109","author":"Johnson C.","journal-title":"J. Nerv. & Ment. Dis."},{"key":"p_36","volume-title":"Jan. '949","author":"Watson J. B."},{"key":"p_38","volume-title":"Oct. 15, 1949.","author":"Goldman"},{"key":"p_39","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1949.00220310080007"},{"key":"p_40","first-page":"357","volume":"33","author":"Landau","year":"1949","journal-title":"Am. J. Syph. Gon. & V. D."},{"key":"p_41","first-page":"234","volume":"33","author":"Klauder V.","year":"1949","journal-title":"Am. J. Syph. Gon. & V. D."},{"issue":"143","key":"p_42","first-page":"i94","volume":"33","author":"Home S. F.","journal-title":"Am. J. Syph. Gon. & V. D."},{"key":"p_43","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-31-1-96"},{"key":"p_44","first-page":"364","volume":"33","author":"Koteen","year":"1949","journal-title":"Am. J. Syph. Gon. & V. D."},{"key":"p_45","first-page":"454","volume":"33","author":"Home S. F","year":"1949","journal-title":"Am. J. Syph. Gon. & V. D."},{"key":"p_46","first-page":"63","volume":"29","author":"Dattner B","year":"1948","journal-title":"J. Ven. Dis. Inform."},{"key":"p_47","volume-title":"Evan W. Syphilis: Its Course and Management","author":"Thomas","year":"1949"},{"issue":"416","key":"p_48","first-page":"949","volume":"33","author":"Wiggall R. H.","journal-title":"Am. J. Syph. Gon. & V. D."},{"key":"p_49","volume-title":"Nov. 1z","author":"Rodriquez J.","year":"1949"},{"key":"p_52","volume-title":"Quite a number of new articles have appeared discussing the results of treatment and some of the theoretical considerations. \"Antabuse","author":"The"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.106.7.522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T12:38:58Z","timestamp":1721824738000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.106.7.522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1950,1]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1950,1]]}},"alternative-id":["10.1176\/ajp.106.7.522"],"URL":"https:\/\/doi.org\/10.1176\/ajp.106.7.522","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[1950,1]]}}}