{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T23:41:21Z","timestamp":1721864481592},"reference-count":10,"publisher":"American Psychiatric Association Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[1959,8]]},"DOI":"10.1176\/ajp.116.2.164","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T18:18:18Z","timestamp":1418840298000},"page":"164-165","source":"Crossref","is-referenced-by-count":1,"title":["POTENTIATION AND FACILITATION OF INSULIN COMA THERAPY"],"prefix":"10.1176","volume":"116","author":[{"given":"J. B.","family":"HAYES","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT E.","family":"KENNEDY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"230","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.128.3338.1570"},{"key":"p_2","volume-title":"The Dynamics of Psychiatric Drug Therapy. Springfield: Charles C Thomas. To be published in June","author":"Lowinger P.","year":"1959"},{"key":"p_3","volume-title":"Department of Internal Medicine","author":"Flinker C.","year":"1959"},{"key":"p_6","volume-title":"There are several variables in the treatment program that have to be considered at all times: 1. The maximum dosage of insulin that may be given to any one patient","author":"One","year":"1958"},{"key":"p_8","volume-title":"Roilman Receiving Hosp. and State Inst. of Psychiatry"},{"key":"p_9","unstructured":"We wish to express our appreciation to Eli Lilly & Company for making supplies of Glucagon available to us, and also to Schering Corporation for their help in supplying us with perphenazine (Trilafon). potentiating effect when used with other therapies. During the past year, all the female patients receiving 1ST obtained satisfactory reactions on a minimal amount of insulin, but many of the male patients on the same treatment showed no effect, even when receiving our maximum amount of 300 units of regular insulin daily. It was found on closer observation, that the female patients also received perphenazine in conjunction with their daily insulin dosage, and that this was not true in the cases of most of the male patients. As a result of this observation, all of the patients on 1ST after this time (1958) were placed on perphenazine, usually in the amount of 4 mgs. q.i.cI. for the female patients, and 8 mgs. q.i.d. for the males. We noted an immediate response to this combined treatment, and were able to produce the desired coma level in all patients, using as little as 25 to 35 units of regular insulin on each daily dose. Coma levels were classified as described by Kalinowsky( 1). A further test of this hypothesis was made when a second course of insulin therapy was given to a male patient who previously had shown absolutely no response, failing even to perspire, after 3 months of daily treatment on 300 units of insulin. During the second course of treatments, this patient also received 8 mgs. of perphenazine q.i.d., and his insulin dosage was always under 300 units a day. He has just completed a course, with coma reactions, with marked improvement."},{"key":"p_14","volume-title":"Psychosurgery","author":"Kalinowsky","year":"1952"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.115.9.814"},{"key":"p_19","volume-title":"thought to be a precursor of acetylcholine is an alized patients","author":"Deanol","year":"1957"},{"key":"p_24","unstructured":"2010 East Meadowbrook Rd., Jackson, Miss. not to interfere with sleep. Shortly thereafter, the number of patients was increased to 100, all institutionalized females, with age range 28 to 82 years. All were schizophrenics, exhibiting apathy, retardation, and depression. Many were mute and inaccessible. The dosage of deanol ranged between 25 mg. and 400 mg. daily, the period of therapy was from 2 to 9 months. Some patients were markedly lethargic from use of reserpine, chlorpromazine, tnfluopromazine and perphenazine; in these patients deanol was used to combat the lethargy."}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.116.2.164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T23:24:57Z","timestamp":1721863497000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.116.2.164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1959,8]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1959,8]]}},"alternative-id":["10.1176\/ajp.116.2.164"],"URL":"https:\/\/doi.org\/10.1176\/ajp.116.2.164","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[1959,8]]}}}