{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:07:50Z","timestamp":1722470870940},"reference-count":9,"publisher":"American Psychiatric Association Publishing","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[1960,12]]},"DOI":"10.1176\/ajp.117.6.557","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T18:21:50Z","timestamp":1418840510000},"page":"557-558","source":"Crossref","is-referenced-by-count":5,"title":["PROLONGED PHENOTHIAZINE HEPATITIS : REPORT OF A CASE"],"prefix":"10.1176","volume":"117","author":[{"given":"BRUCE H.","family":"BAILEY","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Walter Reed General Hospital, WRAMC, Washington 12, D. C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT E.","family":"KAY","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Walter Reed General Hospital, WRAMC, Washington 12, D. C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"230","reference":[{"volume-title":"364, Sept","year":"1952","author":"Pediatrics","key":"p_3"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1007\/BF01584303"},{"key":"p_6","first-page":"2355","volume":"171","author":"Pruitt M.","year":"1959","journal-title":"A. M. A."},{"key":"p_10","unstructured":"Since 1955 a number of reports( 1-3) have discussed the syndrome of chlorpromazine hepatitis. A gastroenteritis, occurring within 2 to 60 days, usually precedes the development of clinically evident jaundice. The incidence of this complication has varied from 0.5 to 4% and the total dose preceding the onset of this reaction has been as little as 150 mg. Hepatitis has occurred as late as two weeks following discontinuation of the drug. It is not known whether this is an allergic or hepatotoxic manifestation. The majority of cases have evidenced clinical and\/or chemical changes indicating intrahepatic obstructive jaundice persisting from one week to 3 months. Cases lasting more than 6 months have been very infrequent. Gebhart, et al.(2) mentioned two patients who had abnormalities persisting for 10 months (laboratory findings not reported). The following case, typical of a chlorpromazine hepatitis, emphasizes the persistence of chemical abnormalities despite clinical improvement and reports results of laboratory tests over an 11 month period."},{"volume-title":"single, male college graduate was hospitalized at another hospital on","year":"1959","author":"This","key":"p_11"},{"key":"p_13","unstructured":"2Tbis material has been reviewed by the Office of the Surgeon General, Department of the Army, and there is no objection to its presentation and\/or pub. lication. This review does not imply any indorsement of the opinions advanced or any recommendation of such products as may be named. vomited, was lethargic and anoreetic, his urine was dark, and scleral icterus was noted. Liver function studies were done at regular intervals. The most significant variations are noted in Table 1. Additional data revealed normal total proteins, thymol turbidity, cephalin flocculation, blood urea nitrogen, non-protein nitrogen, fasting blood sugar, and prothrombin time. The white blood count on April 16, was 6500 with 36% neutrophils, 48% Iymphocytes, 11% eosinophils and 5% monocytes. Repeat white cell counts showed no elevation and normal differential without eosinophilia. Weight loss was prominent in the early months of hospitalization but was enhanced by severe psychotic symptomatology. The patient remained afebrile throughout. Pruritus, of varying degree, heralded initially by a transient, finely papular erythematous rash, occurred intermittently from July through September. His hospital course was characterized by minimal improvement in mental status despite 37 ECT treatments. Other medication given for brief periods during May through August were: probanthine, Benadryl, phenobarbital, Ritalin, meprobamate, amobarbital, atropine, and Anectine. None of these appear to have affected the course of his jaundice. Prochiorperazine (one 30 mg. \"spansule\") was given on May 4, 1959."},{"volume-title":"365","year":"1957","key":"p_29"},{"key":"p_30","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1958.00260180075008"},{"key":"p_31","first-page":"351","volume":"22","author":"Werther J. L.","year":"1957","journal-title":"U. S. Armed Forces J. Med."}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.117.6.557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T05:16:29Z","timestamp":1722402989000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.117.6.557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1960,12]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1960,12]]}},"alternative-id":["10.1176\/ajp.117.6.557"],"URL":"https:\/\/doi.org\/10.1176\/ajp.117.6.557","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"type":"print","value":"0002-953X"},{"type":"electronic","value":"1535-7228"}],"subject":[],"published":{"date-parts":[[1960,12]]}}}