{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T16:33:29Z","timestamp":1722270809141},"reference-count":11,"publisher":"American Psychiatric Association Publishing","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[1965,5]]},"DOI":"10.1176\/ajp.121.11.1115","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T18:30:34Z","timestamp":1418841034000},"page":"1115-1116","source":"Crossref","is-referenced-by-count":4,"title":["BROMIDE INTOXICATION AND ELECTROSHOCK THERAPY"],"prefix":"10.1176","volume":"121","author":[{"given":"GENEVIEVE A.","family":"ARNESON","sequence":"first","affiliation":[{"name":"Louisiana State University, Dept. of Psychiatry and Neurology, and Charity Hospital at New Orleans, La."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT","family":"OURSO","sequence":"additional","affiliation":[{"name":"Louisiana State University, Dept. of Psychiatry and Neurology, and Charity Hospital at New Orleans, La."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"230","reference":[{"key":"p_1","first-page":"1","volume":"9","author":"Weisz S.","year":"1948","journal-title":"Dis. Nerv. Syst."},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.105.7.494"},{"key":"p_3","volume-title":"ibid., 107: 743","author":"Stevenson G. H.","year":"1951"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(54)92259-X"},{"key":"p_9","unstructured":"`Louisiana State University, Dept. of Psychiatry and Neurology, and Charity Hospital at New Orleans, La. mide intoxications admitted to Charity Hospital. Both patients received 3 treatments with the Reiter EST machine-a tonic G.M. followed by 2 minutes of postseizure stimulation. Both patients showed striking and progressive improvement in mental status following EST. With the second patient we decided to measure the bromide level in the CSF since this more accurately reflects the amount of bromide in the brain. Specimens were taken prior to EST and 4 hours afterward. In the pre-EST specimen the bromide level was 214 mg.%; 4 hours after EST it was 176 mg.%, an 18% decrease. We feel this is very significant and supports the hypothesis that EST releases bromide ion from the nervous tissue. This amount of decrease in that time period could not occur unless the EST released bromide. The most rapid way known to reduce the bromide content of the body is by means of haemodialysis, i.e., the artificial kidney. With haemodialysis Wieth and Funder( 1) report that they can reduce the plasma bromide by one-half in 0.8-2.1 hours; however, in the central nervous system the reduction ismuch slower requiring 24 hours to reduce the bromide level by 50% as measured in the CSF. This means that to reduce the CSF bromide level by 18%, it would require 8.5 hours with the patient on the artificial kidney. With EST we apparently achieved this in 4 hours. In any event, this merits further investigation and we invite everyone who has occasion to treat bromide intoxication to attempt to reproduce our findings as we intend to do ourselves."},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)92993-3"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0021-9258(18)74890-4","volume":"113","author":"Mason M. F.","year":"1936","journal-title":"J. Biol. Chem."},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1959.tb49311.x"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5300.295"},{"key":"p_17","first-page":"156","volume":"23","author":"Coppen A. J.","year":"1960","journal-title":"J. Neurol."},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.109.460.395"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.121.11.1115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T12:42:55Z","timestamp":1722256975000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.121.11.1115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1965,5]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1965,5]]}},"alternative-id":["10.1176\/ajp.121.11.1115"],"URL":"https:\/\/doi.org\/10.1176\/ajp.121.11.1115","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[1965,5]]}}}