{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:00:51Z","timestamp":1787018451808,"version":"build-2736575974"},"reference-count":82,"publisher":"American Psychiatric Association Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[1970,8]]},"DOI":"10.1176\/ajp.127.2.199","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T13:37:56Z","timestamp":1418823476000},"page":"199-207","source":"Crossref","is-referenced-by-count":179,"title":["The Role of Brain Dopamine in Behavioral Regulation and the Actions of Psychotropic Drugs"],"prefix":"10.1176","volume":"127","author":[{"given":"SOLOMON H.","family":"SNYDER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KENNETH M.","family":"TAYLOR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JOSEPH T.","family":"COYLE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAMES L.","family":"MEYERHOFF","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"230","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.122.5.509"},{"key":"p_2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1001\/jama.1955.02960260009003","volume":"159","author":"Muller JC","year":"1955","journal-title":"JAMA"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.156.3771.21"},{"key":"p_4","volume-title":"The Uptake and Storage of Noradrenaline in Sympathetic Nerves","author":"Iversen LL","year":"1967"},{"key":"p_5","first-page":"597","volume":"2","author":"Axelrod J","year":"1965","journal-title":"Recent Progr Hormone Res"},{"key":"p_6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0031-6997(25)07220-5","volume":"18","author":"Hillarp NA","year":"1966","journal-title":"Pharmacol Rev"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1962.42.4.554"},{"key":"p_8","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S0031-6997(25)07154-6","volume":"15","author":"Hornykiewicz 0","year":"1966","journal-title":"Pharmacol Rev"},{"key":"p_9","volume-title":"Gellene R: Modification of parkinsonism-chronic treatment with L-DOPA. New Eng J Med 28&.337-345","author":"Cotzias GC","year":"1969"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480160015001"},{"key":"p_11","first-page":"47","volume-title":"Frontiers in Neuroendocrinology","author":"Fuxe K","year":"1969"},{"key":"p_12","volume-title":"Snyder SH: Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas. i Pharmacol Exp Ther 170.221-231","author":"Coyle T","year":"1969"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1967.00470260014002"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1126\/science.166.3907.899"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)61111-4"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401410"},{"key":"p_17","volume-title":"Koe BK","author":"Weissman A","year":"1966"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(66)90272-4"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1007\/BF02148316"},{"key":"p_20","volume-title":"Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats. Psychopharmacologia 10.316-323","author":"Ernst AM","year":"1967"},{"key":"p_21","first-page":"141","volume":"15","author":"Ernst AM","year":"1969","journal-title":"Acta Physiol Pharmacol Neerl"},{"key":"p_22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00404607"},{"key":"p_23","volume-title":"Kanner L: A clinical study of Gilles de la Tourette's disease (maladie des tics) in children. Amer i Psychiat 115:715-723","author":"Eisenberg L","year":"1959"},{"key":"p_24","doi-asserted-by":"publisher","DOI":"10.1007\/BF00343350"},{"key":"p_25","volume-title":"Wick PH: Treatment of acute exacerbations in chronic schizophrenic patients. Int i Neuropsychiat 3(suppl l):61-67","author":"Towler ML","year":"1967"},{"key":"p_26","volume-title":"Clinical efficacy of halopendol in chronic psychotic patients. mt i Neuropsychiat 3(suppl 1):68-77","author":"Lapolla A","year":"1967"},{"key":"p_27","unstructured":"Crane GE A review of clinical literature on haloperidol. J Neuropsychiat 3(suppl l):l 10-127, 1967"},{"key":"p_28","volume-title":"Prospective clinical applications of haloperidol. Int J Neuropsychiat 3(suppl l):232-241","author":"Simpson GM","year":"1967"},{"key":"p_29","volume-title":"Motzenbecker FP Haloperidol in schizophrenic reactions. i Neuropsychiat 4:386-387","author":"Hollister LE","year":"1963"},{"key":"p_30","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(68)90025-3"},{"key":"p_31","volume-title":"Sharman DF: Modification by drugs of the metabolism of 3,4-dihydroxyphenylethylamine, noradrenaline and 5-hydroxytryptamine in the brain. Brit i Pharmacol 24:759-772","author":"Laverty R","year":"1965"},{"key":"p_32","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1961.03040120016004"},{"key":"p_33","volume-title":"Guerrero-Figueroa R: Effects of two butyrophenone compounds on acute schizophrenic patients: speculation on the neurophysiologic sites of action. Int J Neuropsychiat 3(suppl l):53-60","author":"Gallant DM","year":"1967"},{"key":"p_34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0022-3565(25)28335-5","volume":"168","author":"Yeh BK","year":"1969","journal-title":"J Pharmacol Exp Ther"},{"key":"p_35","volume-title":"The pharmacology of halopendol. Int i Neuropsychiat 3(suppl 1): 10-18","author":"Janssen PAJ","year":"1967"},{"key":"p_36","volume-title":"Chapel iL","author":"Challas G","year":"1967"},{"key":"p_37","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.120.3.283"},{"key":"p_38","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.113.497.375"},{"key":"p_39","doi-asserted-by":"publisher","DOI":"10.1007\/BF01564276"},{"key":"p_40","volume-title":"Gilles de Ia Tourette's disease in children: treatment with halopendol. Amer i Psychiat 124:243-245","author":"Lucas AR","year":"1967"},{"key":"p_41","volume-title":"Kauffman PE","author":"Lucas AR","year":"1967"},{"key":"p_42","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.113.499.607"},{"key":"p_43","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.508.345"},{"key":"p_44","volume-title":"Blachly PH: Successful treatment of the maladie des tics. Amer i Dis Child 112:541-545","author":"Stevens JR.","year":"1966"},{"key":"p_45","first-page":"93","volume":"57","author":"Healy NM","year":"1965","journal-title":"i Irish Med Ass"},{"key":"p_46","first-page":"578","volume":"119","author":"Seignot MJN","year":"1961","journal-title":"Ann Medicopsychol"},{"key":"p_47","doi-asserted-by":"crossref","unstructured":"Boris M: Gilles de Ia Tourette's syndrome: remission with halopendol JAMA 205:102-103,","DOI":"10.1001\/jama.1968.03140350058021"},{"key":"p_48","unstructured":"Bieren RE Tourette's disease: successful treatment. iS Carolina Med Ass 65:7-8-1969"},{"key":"p_50","doi-asserted-by":"publisher","DOI":"10.1177\/070674376601100409"},{"key":"p_51","volume-title":"Mass","author":"Ford CV","year":"1968"},{"key":"p_54","unstructured":"16:453-462,"},{"key":"p_55","volume-title":"Milan","author":"Balducci M","year":"1952"},{"key":"p_60","first-page":"1445","volume":"134","author":"Lett CR","year":"1969","journal-title":"Milit Med"},{"key":"p_61","volume-title":"Gilles de Ia Tourette syndrome treated with haloperidol. JAMA 210.134","author":"Craven EM","year":"1969"},{"key":"p_62","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1970.03170040067024"},{"key":"p_63","first-page":"3387","volume":"55","author":"Perini U","year":"1964","journal-title":"Minerva Med"},{"key":"p_64","volume-title":"Koski ML: Syndroma Gilles de Ia Tourette. Acta Paediat Scand 177(suppl):62-63","author":"Kumento A","year":"1967"},{"key":"p_65","volume-title":"Amer i Psychiat 12080-81","author":"Singer K","year":"1963"},{"key":"p_66","volume-title":"Gilles de Ia Tourette's disease. i Ment Sci 105: 1078-1081","author":"Bockner","year":"1959"},{"key":"p_67","volume-title":"Gilles de Ia Tourette's disease. Amer i Psychiat 117:78","author":"Schneck M","year":"1960"},{"key":"p_68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1961.tb01767.x"},{"key":"p_69","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1966.01730080027005"},{"key":"p_70","first-page":"277","volume":"33","author":"Stevens H","year":"1964","journal-title":"Med Ann DC"},{"key":"p_71","volume-title":"Gilles de Ia Tourette's syndrome. Med iAust 1:150-153","author":"Ellison RM","year":"1964"},{"key":"p_72","volume-title":"Gilles de Ia Tourette syndrome treatment by bimedial frontal leucotomy. Canad Med Ass i 86:746-747","author":"Baker EFW","year":"1962"},{"key":"p_73","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1742-1241.1962.tb04656.x","volume":"16","author":"Walsh PJF","year":"1962","journal-title":"Brit J Clin Pract"},{"key":"p_74","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-196801000-00004"},{"key":"p_75","volume-title":"Gilles de Ia Tourette's disease in children: treatment with phenothiazine drugs. Amer i Psychiat 12 1:606-608","author":"Lucas AR","year":"1964"},{"key":"p_76","volume-title":"Gilles de la Tourette syndrome treatment with LSD. Irish i Med Sci 2:269-271","author":"Smith CG","year":"1969"},{"key":"p_77","volume-title":"Kloss M: Dc Ia maladie de Gilles de Ia Tourette. Ann Medicopsychol 120.225-232","author":"Dolmierski R","year":"1962"},{"key":"p_78","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1965.tb00959.x"},{"key":"p_79","volume-title":"Maladie des tics in children. Amer i Psychiat 116:177-178","author":"Rapoport J","year":"1959"},{"key":"p_80","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.114.506.123-a"},{"key":"p_81","volume-title":"i Pediatll:417-419","author":"Barsky","year":"1967"},{"key":"p_82","volume-title":"A case of Gilles de la Tourette syndrome with some aetiological observations. Brit i Psychiat 109:206-2 10","author":"MacDonald Ii","year":"1963"},{"key":"p_83","doi-asserted-by":"publisher","DOI":"10.1007\/BF01561841"},{"key":"p_84","volume-title":"Multiple tics. Amer i Psychiat 116: 935-936","author":"Milman DH","year":"1960"},{"key":"p_85","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-194605000-00001"},{"key":"p_86","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-440X(65)80023-2"},{"key":"p_87","volume-title":"Behavior therapy of Gilles de Ia Tourette's syndrome. Brit i Psychiat 112:771-778","author":"Clark DF","year":"1966"},{"key":"p_88","volume-title":"i Child Psychol Psychiat 2:148-155","author":"Walton D","year":"1961"},{"key":"p_89","first-page":"1506","volume":"1","author":"Michael RP","year":"1957","journal-title":"Brit Mcdi"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.127.2.199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:11:57Z","timestamp":1747188717000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/ajp.127.2.199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,8]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1970,8]]}},"alternative-id":["10.1176\/ajp.127.2.199"],"URL":"https:\/\/doi.org\/10.1176\/ajp.127.2.199","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,8]]}}}