{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:37:45Z","timestamp":1780367865704,"version":"3.54.1"},"reference-count":13,"publisher":"American Psychiatric Association Publishing","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[2004,9,1]]},"DOI":"10.1176\/appi.ajp.161.9.1700","type":"journal-article","created":{"date-parts":[[2004,8,30]],"date-time":"2004-08-30T21:38:21Z","timestamp":1093901901000},"page":"1700-1702","source":"Crossref","is-referenced-by-count":109,"title":["Effects of a Functional COMT Polymorphism on Prefrontal Cognitive Function in Patients With 22q11.2 Deletion Syndrome"],"prefix":"10.1176","volume":"161","author":[{"given":"Carrie E.","family":"Bearden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas F.","family":"Jawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Set","family":"Sokol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Kanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"McDonald-McGinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulagna C.","family":"Saitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy E.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Moss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul P.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Zackai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly S.","family":"Emanuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony J.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"230","reference":[{"key":"R1619BABHIAAC","doi-asserted-by":"crossref","unstructured":"Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM: Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996; 6:243\u2013250","DOI":"10.1097\/00008571-199606000-00007"},{"key":"R1619BABJEGFG","doi-asserted-by":"crossref","unstructured":"Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR: Effect of COMT Val108\/158Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001; 98:6917\u20136922","DOI":"10.1073\/pnas.111134598"},{"key":"R1619BABFEEJE","doi-asserted-by":"crossref","unstructured":"Graf WD, Unis AS, Yates CM, Sulzbacher S, Dinulos MB, Jack RM, Dugaw KA, Paddock MN, Parson WW: Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism. Neurology 2001; 57:410\u2013416","DOI":"10.1212\/WNL.57.3.410"},{"key":"R1619BABCDGGA","doi-asserted-by":"crossref","unstructured":"Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T, Goldman D: A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 2002; 159:652\u2013654","DOI":"10.1176\/appi.ajp.159.4.652"},{"key":"R1619BABEECGI","doi-asserted-by":"crossref","unstructured":"Grossman MH, Emanuel BS, Budarf ML: Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1-q11.2. Genomics 1992; 12:822\u2013825","DOI":"10.1016\/0888-7543(92)90316-K"},{"key":"R1619BABEICIA","doi-asserted-by":"crossref","unstructured":"McDonald-McGinn DM, LaRossa D, Randall P, Emanuel BS, Zackai EH: The 22q11.2 deletion: screening, diagnostic workup, and outcome. Genet Test 1997; 1:99\u2013108","DOI":"10.1089\/gte.1997.1.99"},{"key":"R1619BABGCJDJ","doi-asserted-by":"crossref","unstructured":"Woodin M, Wang PP, Aleman D, McDonald-McGinn D, Zackai E, Moss E: Neuropsychological profile of children and adolescents with the 22q11.2 microdeletion. Genet Med 2001; 3:34\u201339","DOI":"10.1097\/00125817-200101000-00008"},{"key":"R1619BABFHDCD","doi-asserted-by":"crossref","unstructured":"Bearden CE, Woodin M, Wang PP, Moss E, McDonald-McGinn D, Zackai E, Emanuel B, Cannon TD: Neuropsychological function in the 22q deletion syndrome. J Clin Exp Neuropsychol 2001; 23:447\u2013464","DOI":"10.1076\/jcen.23.4.447.1228"},{"key":"R1619BABHGEGE","doi-asserted-by":"crossref","unstructured":"Bassett AS, Chow EW: 22q11 deletion syndrome: a genetic subtype of schizophrenia. Biol Psychiatry 1999; 46:882\u2013891","DOI":"10.1016\/S0006-3223(99)00114-6"},{"key":"R1619BABDDIHB","doi-asserted-by":"crossref","unstructured":"Murphy KC, Jones LA, Owen MJ: High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry 1999; 56:940\u2013945","DOI":"10.1001\/archpsyc.56.10.940"},{"key":"R1619BABECEDI","doi-asserted-by":"crossref","unstructured":"Papolos DF, Faedda GL, Veit S, Goldberg R, Morrow B, Kucherlapati R, Shprintzen RJ: Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? Am J Psychiatry 1996; 153:1541\u20131547","DOI":"10.1176\/ajp.153.12.1541"},{"key":"R1619BABFHABJ","doi-asserted-by":"crossref","unstructured":"Lynch DR, Mozley D, Sokol S, Maas NMC, Balcer LJ, Siderowf AD: Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson\u2019s disease. Movement Disord 2003; 18:804\u2013812","DOI":"10.1002\/mds.10430"},{"key":"R1619BABJICHE","doi-asserted-by":"crossref","unstructured":"Karayiorgou M, Gogos JA, Galke BL, Wolyniec PS, Nestadt G, Antonarakis SE, Kazazian HH, Housman DE, Pulver AE: Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility. Biol Psychiatry 1998; 43:425\u2013431","DOI":"10.1016\/S0006-3223(97)00202-3"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.161.9.1700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,28]],"date-time":"2024-07-28T11:51:15Z","timestamp":1722167475000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.161.9.1700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,1]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9,1]]}},"alternative-id":["10.1176\/appi.ajp.161.9.1700"],"URL":"https:\/\/doi.org\/10.1176\/appi.ajp.161.9.1700","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,1]]}}}