{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:48:17Z","timestamp":1788911297070,"version":"build-2803163510"},"reference-count":73,"publisher":"American Psychiatric Association Publishing","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[2025,8,1]]},"DOI":"10.1176\/appi.ajp.20240445","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T03:00:48Z","timestamp":1749610848000},"page":"763-778","source":"Crossref","is-referenced-by-count":7,"title":["Copy Number Variant Architecture of Child Psychopathology and Cognitive Development in the ABCD Study"],"prefix":"10.1176","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6604-6202","authenticated-orcid":false,"given":"Zhiqiang","family":"Sha","sequence":"first","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Y.","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8906-8452","authenticated-orcid":false,"given":"Benjamin","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3247-2331","authenticated-orcid":false,"given":"Ran","family":"Barzilay","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler M.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Almasy","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Forsyth","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smrithi","family":"Prem","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Gandal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Seidlitz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"Glessner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-1893","authenticated-orcid":false,"given":"Aaron F.","family":"Alexander-Bloch","sequence":"additional","affiliation":[{"name":"Department of Psychiatry (Sha, Sun, Barzilay, Moore, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung) and Department of Genetics (Almasy, Gandal), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Department of Child and Adolescent Psychiatry and Behavioral Science (Sha, Sun, Barzilay, Prem, Seidlitz, Alexander-Bloch, Jung), Department of Biomedical and Health Informatics (Almasy), and Center for Applied Genomics (Glessner), Children\u2019s Hospital of Philadelphia, Philadelphia; Lifespan Brain Institute, Children\u2019s Hospital of Philadelphia and Penn Medicine, Philadelphia (Sha, Sun, Barzilay, Moore, Almasy, Prem, Gandal, Seidlitz, Alexander-Bloch, Jung); Department of Psychology, University of Washington, Seattle (Forsyth)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"230","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)30376-5"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00774-6"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.05.004"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2017.12.004"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nature07953"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nature09146"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002464"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.19090923"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3725"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0566-4"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/wps.21037"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nature08494"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/nature08516"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2009.10.006"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nature12818"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-008-0026-1"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2021.01.007"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01906-y"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1177\/1745691618810696"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.17121383"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2017.02.003"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.21111175"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.1017"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2017.10.002"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1101\/gr.6861907"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm076"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.03.005"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2495-7"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.09.002"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000529"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-023-10143-0"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz633"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2018.0039"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2958"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nature09298"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.016"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.01.028"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddad074"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2017.10.010"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0736-6"},{"key":"B41","volume-title":"Achenbach System of Empirically Based Assessment (ASEBA): Development, Findings, Theory, and Applications","author":"Achenbach TM","year":"2009"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.02.006"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182872e5f"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-022-01222-7"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1346"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.304458"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13624-1"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0494-1"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1086\/383251"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/sj.hdy.6800717"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2308-7"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.036"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/nature19057"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14774"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0740-z"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182166df5"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32643"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36032"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.03.010"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-114"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.039"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-01978-4"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12416"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-022-01245-2"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1186\/s13039-020-00527-w"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.08.014"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.19080834"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2022.02.010"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.5808\/GI.2012.10.2.117"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705554105"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/915636"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22387"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22537"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:00:44Z","timestamp":1754031644000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20240445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":73,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,1]]}},"alternative-id":["10.1176\/appi.ajp.20240445"],"URL":"https:\/\/doi.org\/10.1176\/appi.ajp.20240445","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]}}}