{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:01:04Z","timestamp":1787018464009,"version":"build-2736575974"},"reference-count":105,"publisher":"American Psychiatric Association Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[2026,1,1]]},"DOI":"10.1176\/appi.ajp.20241084","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T05:04:31Z","timestamp":1765343071000},"page":"58-69","source":"Crossref","is-referenced-by-count":4,"title":["Imaging Metabotropic Glutamate Receptor 5 and Excitatory Neural Activity in Autism"],"prefix":"10.1176","volume":"183","author":[{"given":"Adam J.","family":"Naples","sequence":"first","affiliation":[{"name":"Center for Brain and Mind Health, Yale University, New Haven, CT."},{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gravel","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Toyonaga","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faranak Ebrahimian","family":"Sadabad","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheida","family":"Koohsari","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Dominique","family":"Gallezot","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Pisani","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Finn","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Cramer-Benjamin","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Herman","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey H.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra J.","family":"Franke","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget M.","family":"Walicki","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel G.","family":"Rodden","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansel T.","family":"Hillmer","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."},{"name":"Department of Psychiatry, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Esterlis","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."},{"name":"Department of Psychiatry, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Ropchan","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel","family":"Nabulsi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"McPartland","sequence":"additional","affiliation":[{"name":"Center for Brain and Mind Health, Yale University, New Haven, CT."},{"name":"Child Study Center, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Matuskey","sequence":"additional","affiliation":[{"name":"Center for Brain and Mind Health, Yale University, New Haven, CT."},{"name":"Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT."},{"name":"Department of Psychiatry, Yale University, New Haven, CT."},{"name":"Department of Neurology, Yale University, New Haven, CT."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"230","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.161.4.343"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0566s66"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3992"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.10.008"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-183X.2003.00037.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10360"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.02.002.2008"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/286073"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.102"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00609"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-1-12"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/486402"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2784-12.2012"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.11.009"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31286"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30229"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-4-21"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10658"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.02.006"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/wmts.30"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20783"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806139200"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00199"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.01.016"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.08.008"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.04.009"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-13-05196.1997"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.05.009"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11459"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80810-7"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.258384"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035003"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21299"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.009"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003501"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738221089740"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/20503121241282401"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01860-9"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40673-018-0082-1"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22062863"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02143-1"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.65"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94967-y"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10120899"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.07.033"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2022.03.011"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.04.030"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75893-x"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01796-2"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2300"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2023.111745"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.53"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.21050485"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-022-00526-1"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02218-z"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.4979043"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-021-05395-w"},{"key":"e_1_3_2_59_2","volume-title":"Autism Diagnostic Observation Schedule","author":"Lord C","year":"2012","unstructured":"Lord C, Rutter M, DiLavore PC, et al: Autism Diagnostic Observation Schedule, 2nd ed. Torrance, CA, Western Psychological Services, 2012","edition":"2"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19886316"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.58"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2017.03.019"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2014.09.006"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.195"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-015-3094-6"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.4819820"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00171"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1836"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00050-2"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.12.005"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4276"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00744-x"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118217"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.09.029"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196964"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00420"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-5-41"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.07.014"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2021.760116"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyae031"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.006"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16668891"},{"key":"e_1_3_2_86_2","unstructured":"Mecca AP Salardini E Gallezot JD et al: A phase 1a single ascending dose study of the safety tolerability and brain receptor occupancy of BMS-984923 in healthy older adults. Paper presented at the Clinical Trials on Alzheimer\u2019s Disease Conference (CTAD) October 24\u201327 2023 Boston"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0426-0"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0037665"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2010.00224"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.70255"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47316-0"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.01.024"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.28751"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2019.03.009"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2015.7"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2020.00016"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.12.026"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2019.04.013"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-019-03903-7"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-014-2170-2"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21890"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2020.00021"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00388.2019"},{"key":"e_1_3_2_104_2","first-page":"693","article-title":"Generalized slowing of resting-state neural oscillations in people with schizophrenia","volume":"10","author":"Sponheim SR","year":"2024","unstructured":"Sponheim SR, Ramsay IS, Lynn PA, et al: Generalized slowing of resting-state neural oscillations in people with schizophrenia. Biol Psychiatry Cogn Neurosci Neuroimaging 2024; 10:693\u2013698","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2016_40"},{"key":"e_1_3_2_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2011.04.010"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:35:14Z","timestamp":1773660914000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20241084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["10.1176\/appi.ajp.20241084"],"URL":"https:\/\/doi.org\/10.1176\/appi.ajp.20241084","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]}}}