{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:29:29Z","timestamp":1793305769289,"version":"4.5.0"},"reference-count":64,"publisher":"American Psychiatric Association Publishing","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[2026,10,1]]},"DOI":"10.1176\/appi.ajp.20250198","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:00:24Z","timestamp":1783483224000},"page":"785-796","source":"Crossref","is-referenced-by-count":3,"title":["Convergent Network Localization of Brain Stimulation Targets for Trait Anxiety"],"prefix":"10.1176","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0967-9289","authenticated-orcid":false,"given":"Shan H.","family":"Siddiqi","sequence":"first","affiliation":[{"name":"Center for Brain Circuit Therapeutics, Brigham and Women\u2019s Hospital, Boston."},{"name":"Department of Psychiatry, Mass General Brigham, Harvard Medical School, Boston."},{"name":"Dauten Behavioral Health Institute, Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Klingbeil","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Leipzig Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Webler","sequence":"additional","affiliation":[{"name":"Center for Brain Circuit Therapeutics, Brigham and Women\u2019s Hospital, Boston."},{"name":"Department of Psychiatry, Mass General Brigham, Harvard Medical School, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9122-4525","authenticated-orcid":false,"given":"Ian H.","family":"Kratter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Blumberger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto."},{"name":"Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Fox","sequence":"additional","affiliation":[{"name":"Center for Brain Circuit Therapeutics, Brigham and Women\u2019s Hospital, Boston."},{"name":"Department of Psychiatry, Mass General Brigham, Harvard Medical School, Boston."},{"name":"Department of Neurology, Harvard Medical School, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Medical University of South Carolina, Charleston."},{"name":"Ralph H. Johnson Veterans Affairs Hospital, Charleston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan H.","family":"Grafman","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Shirley Ryan AbilityLab, Northwestern University Feinberg School of Medicine, Chicago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8975-0382","authenticated-orcid":false,"given":"Alvaro","family":"Pascual-Leone","sequence":"additional","affiliation":[{"name":"Department of Neurology, Harvard Medical School, Boston."},{"name":"Hinda and Arthur Marcus Institute for Aging Research, Deanna and Sidney Wolk Center for Memory Health, Hebrew SeniorLife, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6968-2829","authenticated-orcid":false,"given":"Andrew R.","family":"Pines","sequence":"additional","affiliation":[{"name":"Center for Brain Circuit Therapeutics, Brigham and Women\u2019s Hospital, Boston."},{"name":"Department of Psychiatry, Mass General Brigham, Harvard Medical School, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Mark","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Talati","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-8820","authenticated-orcid":false,"given":"Fidel","family":"Vila-Rodriguez","sequence":"additional","affiliation":[{"name":"Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry and School of Biomedical Engineering, University of British Columbia, Vancouver."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Downar","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Hershey","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Radiology, Neurology and Neuroscience, Washington University School of Medicine, St. Louis, MO."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-9567","authenticated-orcid":false,"given":"Kevin J.","family":"Black","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, Radiology, Neurology and Neuroscience, Washington University School of Medicine, St. Louis, MO."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"230","reference":[{"key":"e_1_3_2_2_2","volume-title":"Depression and Other Common Mental Disorders: Global Health Estimates","author":"World Health Organization","year":"2017","unstructured":"World Health Organization: Depression and Other Common Mental Disorders: Global Health Estimates. Geneva, World Health Organization, 2017"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/13651500600552297"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.595584"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.22m14571"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2019-100051"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19090915"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24204"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.neuropsych.11030060"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-022-00583-8"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-021-01161-1"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01834-y"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac009"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.1988"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26468"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25285"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2023.09.006"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0685-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03057-9"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117307"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24974"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2014.06.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.20344\/amp.4928"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01978-y"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-025-02196-7"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22947"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20230015"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.01.018"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.46"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1797"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000500188"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.4534"},{"key":"e_1_3_2_35_2","article-title":"A potential neuromodulation target for PTSD in veterans derived from focal brain lesions","author":"Siddiqi S","year":"2024","unstructured":"Siddiqi S, Philip NS, Palm S, et al: A potential neuromodulation target for PTSD in veterans derived from focal brain lesions. Res Sq (preprint March 19, 2024)","journal-title":"Res Sq"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001085"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.11.011"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00579-9"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68008-z"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116287"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.11.013"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6185(01)00060-3"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01155.x"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.2.318"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2022.06.003"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/psyrad\/kkad007"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-024-01918-y"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25577"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118052"},{"key":"e_1_3_2_50_2","article-title":"Revisiting the methodological foundation of lesion network mapping","author":"Petersen M","year":"2026","unstructured":"Petersen M, Patil KR, Eickhoff SB, et al: Revisiting the methodological foundation of lesion network mapping. medRxiv 2026.02.16.26346377, 2026","journal-title":"medRxiv"},{"key":"e_1_3_2_51_2","article-title":"The diversity of lesion network mapping findings","author":"Meng Y","year":"2026","unstructured":"Meng Y, Xu W, Jiang J, et al: The diversity of lesion network mapping findings. bioRxiv 2026.02.12.705312, 2026","journal-title":"bioRxiv"},{"key":"e_1_3_2_52_2","article-title":"The methodological foundations of lesion network mapping remain sound","author":"Siddiqi SH","year":"2026","unstructured":"Siddiqi SH, Horn A, Schaper FLWVJ, et al: The methodological foundations of lesion network mapping remain sound. bioRxiv 2026.02.24.707529, 2026","journal-title":"bioRxiv"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20030305"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-026-03535-1"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.165271"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.10.020"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.09.009"},{"key":"e_1_3_2_58_2","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Chandler J","year":"2019","unstructured":"Chandler J, Cumpston M, Li T: Completing \u201cSummary of findings\u201d tables and grading the certainty of the evidence; in Cochrane Handbook for Systematic Reviews of Interventions. Hoboken, Wiley, 2019"},{"key":"e_1_3_2_59_2","article-title":"Focal brain stimulation sites that modify autonomic arousal map to a convergent brain circuit and potential therapeutic target","author":"Webler RD","year":"2026","unstructured":"Webler RD, Neudorfer C, Dijkstra ESA, et al: Focal brain stimulation sites that modify autonomic arousal map to a convergent brain circuit and potential therapeutic target. bioRxiv 2026.01.08.698446, 2026","journal-title":"bioRxiv"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.10.028"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2012.02.003"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2013.01.003"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.039068"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20220306"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30295-2"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:00:53Z","timestamp":1790827253000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20250198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":64,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1176\/appi.ajp.20250198"],"URL":"https:\/\/doi.org\/10.1176\/appi.ajp.20250198","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}