{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:28:40Z","timestamp":1793021320420,"version":"4.5.0"},"reference-count":70,"publisher":"American Psychiatric Association Publishing","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[2025,10,1]]},"DOI":"10.1176\/appi.ajp.20250276","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T07:00:46Z","timestamp":1757487646000},"page":"903-912","source":"Crossref","is-referenced-by-count":15,"title":["Ketamine for Depression, but at What Cost? A Review of Ketamine\u2019s Neurotoxic Effects From Preclinical and Human Studies"],"prefix":"10.1176","volume":"182","author":[{"given":"S. William","family":"Li","sequence":"first","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina T.","family":"Kumpf","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven;"},{"name":"Child Study Center, School of Medicine, Yale University, New Haven."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Urrutia","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Krystal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Sanacora","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel T.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine, Yale University, New Haven;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"230","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-023-01632-1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1903305"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.21111086"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.2660263"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2022.2071867"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.01.008"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-053013-062946"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.005"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.255"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nature17998"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18020138"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.672526"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.07.008"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.08.036"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn270"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2174\/157015911795017155"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2021.106993"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1177\/10915818231176971"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.08.009"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.07.059"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.00060"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2018.12.002"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0793-6"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.111928"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120959644"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2024.149311"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006851"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm084"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2009.06.010"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2011.01.001"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.07.022"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12004"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00285"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134702"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2011.11.001"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(02)00194-1"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyae046"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19m12891"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-023-01577-5"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2302399"},{"key":"B43","author":"Kosik-Gonzalez C","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0572-3"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2011.03576.x"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.21134\/haaj.v24i1.782"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02761.x"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02394.x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2022.795231"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2013.74.460"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2004.00879.x"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2019.106081"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.645471"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2018.05.050"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00149"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108063"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnv112"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2007.00314.x"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.624"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.04.141"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.12.097"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.05.131"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.07.004"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.52965\/001c.38247"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.04.035"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2017.17020239"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12099"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0383-6"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00074"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.015198"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.12.014"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:49:14Z","timestamp":1761598154000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20250276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,1]]}},"alternative-id":["10.1176\/appi.ajp.20250276"],"URL":"https:\/\/doi.org\/10.1176\/appi.ajp.20250276","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]}}}