{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:08:41Z","timestamp":1788926921171,"version":"build-2803163510"},"reference-count":57,"publisher":"American Psychiatric Association Publishing","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"DOI":"10.1176\/appi.ajp.20251163","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:00:13Z","timestamp":1788926413000},"source":"Crossref","is-referenced-by-count":0,"title":["Sex-Moderated and Sex-Specific Effects of Adverse Childhood Experiences on Neural Alcohol Cue Reactivity and Daily Craving in Individuals With Alcohol Use Disorder"],"prefix":"10.1176","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3396-4129","authenticated-orcid":false,"given":"Lilli","family":"R\u00f6tzer","sequence":"first","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."},{"name":"German Center for Mental Health (DZPG), Mannheim-Heidelberg-Ulm Partner Site, Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2863-8284","authenticated-orcid":false,"given":"Judith","family":"Zaiser","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."},{"name":"German Center for Mental Health (DZPG), Mannheim-Heidelberg-Ulm Partner Site, Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-2939","authenticated-orcid":false,"given":"Sabine","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."},{"name":"German Center for Mental Health (DZPG), Mannheim-Heidelberg-Ulm Partner Site, Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9809-5500","authenticated-orcid":false,"given":"Inka","family":"Hi\u00df","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."},{"name":"German Center for Mental Health (DZPG), Mannheim-Heidelberg-Ulm Partner Site, Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8215-1678","authenticated-orcid":false,"given":"Iris","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6580-6326","authenticated-orcid":false,"given":"Christine","family":"Heim","sequence":"additional","affiliation":[{"name":"Institute of Medical Psychology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin."},{"name":"NeuroCure Cluster of Excellence, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Berlin."},{"name":"German Center for Mental Health, Berlin-Potsdam Partner Site, Berlin."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-7569","authenticated-orcid":false,"given":"Heike","family":"Tost","sequence":"additional","affiliation":[{"name":"German Center for Mental Health (DZPG), Mannheim-Heidelberg-Ulm Partner Site, Mannheim, Germany."},{"name":"Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7213-0398","authenticated-orcid":false,"given":"Falk","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."},{"name":"German Center for Mental Health (DZPG), Mannheim-Heidelberg-Ulm Partner Site, Mannheim, Germany."},{"name":"Feuerlein Center on Translational Addiction Medicine, University of Heidelberg, Heidelberg, Germany."},{"name":"Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-0924","authenticated-orcid":false,"given":"Bernd","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."},{"name":"German Center for Mental Health (DZPG), Mannheim-Heidelberg-Ulm Partner Site, Mannheim, Germany."},{"name":"Feuerlein Center on Translational Addiction Medicine, University of Heidelberg, Heidelberg, Germany."},{"name":"Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5962-019X","authenticated-orcid":false,"given":"Patrick","family":"Bach","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."},{"name":"German Center for Mental Health (DZPG), Mannheim-Heidelberg-Ulm Partner Site, Mannheim, Germany."},{"name":"Feuerlein Center on Translational Addiction Medicine, University of Heidelberg, Heidelberg, Germany."},{"name":"Department of Clinical Neuroscience, Karolinska Institute, Stockholm."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"230","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31775-1"},{"key":"e_1_3_2_3_2","volume-title":"Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and by Region, 2000\u20132019","author":"World Health Organization","year":"2020","unstructured":"World Health Organization: Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and by Region, 2000\u20132019. Geneva, World Health Organization, 2020"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu038"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(98)00017-8"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-005-0624-4"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42844-020-00005-7"},{"key":"e_1_3_2_8_2","first-page":"05","article-title":"The role of stress, trauma, and negative affect in alcohol misuse and alcohol use disorder in women","volume":"40","author":"Guinle MIB","year":"2020","unstructured":"Guinle MIB, Sinha R: The role of stress, trauma, and negative affect in alcohol misuse and alcohol use disorder in women. Alcohol Res 2020; 40:05","journal-title":"Alcohol Res"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000494766"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1077559515591270"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2023.2171301"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2005.01.015"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.08.023"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/10826088909047272"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2024.2419540"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2012.00464.x"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.06.031"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.048"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.10.049"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.40018"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20230849"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.12.004"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.24641"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3758\/s13428-022-02019-8"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1657-6"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12866"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00352.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2023.08.024"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20230027"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_3_2_31_2","first-page":"109","article-title":"A brief instrument for the assessment of childhood abuse and neglect: the childhood trauma screener (CTS)","volume":"39","author":"Grabe HJ","year":"2012","unstructured":"Grabe HJ, Schulz A, Schmidt CO, et al: A brief instrument for the assessment of childhood abuse and neglect: the childhood trauma screener (CTS) (article in German). Psychiatr Prax 2012; 39:109\u2013115","journal-title":"Psychiatr Prax"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13034-022-00506-6"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700048017"},{"key":"e_1_3_2_34_2","first-page":"79","volume-title":"Functional Neuroimaging: Technical Foundations","author":"Friston KJ","year":"1994","unstructured":"Friston KJ: Statistical parametric mapping; in Functional Neuroimaging: Technical Foundations. Edited by Thatcher RW, Hallett M, Zeffiro TA, et al. San Diego, Academic Press, 1994, pp 79\u201393"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.3.022806.091415"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.54.101601.145030"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0978"},{"key":"e_1_3_2_38_2","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach","author":"Hayes AF","year":"2013","unstructured":"Hayes AF: Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach. New York, Guilford, 2013"},{"key":"e_1_3_2_39_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2022","unstructured":"R Core Team: R: A Language and Environment for Statistical Computing. Vienna, R Foundation for Statistical Computing, 2022"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1441.030"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)00104-8"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108519"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.206"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600965113"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2020.104752"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.037"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.05030503"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/10673220902899680"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-199811000-00018"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.02.006"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2021.1969658"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.37192"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.17.2003"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.1240"},{"key":"e_1_3_2_55_2","first-page":"664","article-title":"Smoking as an outcome moderator in the treatment of alcohol use disorders","volume":"57","author":"van Amsterdam J","year":"2022","unstructured":"van Amsterdam J, van den Brink W: Smoking as an outcome moderator in the treatment of alcohol use disorders. Alcohol Alcohol 2022; 57:664\u2013673","journal-title":"Alcohol Alcohol"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2830-x"},{"key":"e_1_3_2_57_2","volume-title":"Intensive Longitudinal Methods: An Introduction to Diary and Experience Sampling Research","author":"Bolger N","year":"2013","unstructured":"Bolger N, Laurenceau J-P: Intensive Longitudinal Methods: An Introduction to Diary and Experience Sampling Research. Guilford, 2013"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(24)00330-4"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:00:15Z","timestamp":1788926415000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20251163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":57,"alternative-id":["10.1176\/appi.ajp.20251163"],"URL":"https:\/\/doi.org\/10.1176\/appi.ajp.20251163","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"article-number":"appi.ajp.20251163"}}