{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:15:22Z","timestamp":1788239722786,"version":"build-2803163510"},"reference-count":131,"publisher":"American Psychiatric Association Publishing","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP"],"published-print":{"date-parts":[[2026,9,1]]},"DOI":"10.1176\/appi.ajp.20260362","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:22:48Z","timestamp":1788236568000},"page":"615-623","source":"Crossref","is-referenced-by-count":0,"title":["New Horizons in the Development of Treatments for Substance Use Disorders"],"prefix":"10.1176","volume":"183","author":[{"given":"John J.","family":"Mariani","sequence":"first","affiliation":[{"name":"Division on Substance Use Disorders, New York State Psychiatric Institute, New York."},{"name":"Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances R.","family":"Levin","sequence":"additional","affiliation":[{"name":"Division on Substance Use Disorders, New York State Psychiatric Institute, New York."},{"name":"Department of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"230","reference":[{"key":"e_1_3_2_2_2","unstructured":"Substance Abuse and Mental Health Services Administration: Key Substance Use and Mental Health Indicators in the United States: Results From the 2024 National Survey on Drug Use and Health 2025. https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/reports\/rpt56287\/2024-nsduh-annual-national-report.pdf"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Garnett MF Mini\u00f1o AM: Drug Overdose Deaths in the United States 2023\u20132024 (Data Brief No 549). National Center for Health Statistics January 29 2026. https:\/\/www.cdc.gov\/nchs\/products\/databriefs\/db549.htm","DOI":"10.15620\/cdc\/174639"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Tejada-Vera B Bastian BA Curtin SC: Deaths: Leading Causes for 2023. Natl Vital Stat Rep 2025; 74(10):1\u2013115. https:\/\/dx.doi.org\/10.15620\/cdc\/174607","DOI":"10.15620\/cdc\/174607"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7302a1"},{"key":"e_1_3_2_6_2","unstructured":"CDC: Facts about US deaths from excessive alcohol use. Alcohol Use 2025. https:\/\/www.cdc.gov\/alcohol\/facts-stats\/index.html"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20230488"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.15288\/jsads.2014.s17.68"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2017.01.008"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026839"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agy089"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agae042"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/indianjpsychiatry.indianjpsychiatry_820_23"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19761"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0101-y"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2024.2445734"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40290-024-00526-x"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2025.2508"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.4789"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2817"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.59016"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.70007"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000003162"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000741"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agaf032"},{"key":"e_1_3_2_26_2","first-page":"CD008940","article-title":"Pharmacotherapies for cannabis use disorder","volume":"9","author":"Spiga F","year":"2025","unstructured":"Spiga F, Parkhouse T, Tang VM, et al: Pharmacotherapies for cannabis use disorder. Cochrane Database Syst Rev 2025; 9:CD008940","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.12.010"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.11.025"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.1993"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.867878"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-024-02498-5"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/add.70084"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2021.108765"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-018-9813-6"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20230508"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2017.12.007"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2023.03.004"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2025.104889"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2025.112957"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2026.113048"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.1035345"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/add.16624"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.0395"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000002057"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10042"},{"key":"e_1_3_2_46_2","first-page":"CD013229","article-title":"Behavioural interventions for smoking cessation: an overview and network meta-analysis","volume":"1","author":"Hartmann-Boyce J","year":"2021","unstructured":"Hartmann-Boyce J, Livingstone-Banks J, Ord\u00f3\u00f1ez-Mena JM, et al: Behavioural interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev 2021; 1:CD013229","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826084.2022.2161317"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2025.05.005"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115340"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2023.10.002"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2025.127036"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.36416\/1806-3756\/e20250061"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-023-08137-z"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.26348"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2025.2507124"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32812-X"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2025.112789"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/add.70212"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.52136"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.28119"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12954-025-01353-2"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2025.12.004"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5c00970"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40429-023-00476-5"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-024-01524-1"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115318"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2023.111040"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244401"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2018.1052"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32259-1"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.37319"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.17377"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.47965"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.126006"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.013904"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112368"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2023.2173062"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyaf005"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c02860"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpet.2025.103522"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108060"},{"key":"e_1_3_2_82_2","first-page":"CD011866","article-title":"Psychosocial interventions for stimulant use disorder","volume":"2","author":"Minozzi S","year":"2024","unstructured":"Minozzi S, Saulle R, Amato L, et al: Psychosocial interventions for stimulant use disorder. Cochrane Database Syst Rev 2024; 2:CD011866","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002715"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.8049"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108307"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcbs.2019.07.003"},{"key":"e_1_3_2_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2023.111078"},{"key":"e_1_3_2_88_2","doi-asserted-by":"publisher","DOI":"10.1080\/10550887.2024.2327762"},{"key":"e_1_3_2_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.107648"},{"key":"e_1_3_2_90_2","doi-asserted-by":"publisher","DOI":"10.1037\/adb0001107"},{"key":"e_1_3_2_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2025.112993"},{"key":"e_1_3_2_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.josat.2025.209752"},{"key":"e_1_3_2_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2025.112642"},{"key":"e_1_3_2_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2025.107954"},{"key":"e_1_3_2_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2025.174056"},{"key":"e_1_3_2_96_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-020-05563-3"},{"key":"e_1_3_2_97_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2020214"},{"key":"e_1_3_2_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.107700"},{"key":"e_1_3_2_99_2","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13271"},{"key":"e_1_3_2_100_2","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000676"},{"key":"e_1_3_2_101_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12111593"},{"key":"e_1_3_2_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2025.112765"},{"key":"e_1_3_2_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22087-1"},{"key":"e_1_3_2_104_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi4505"},{"key":"e_1_3_2_105_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.3655"},{"key":"e_1_3_2_106_2","first-page":"e102744","article-title":"Naltrexone\/bupropion\/mirtazapine triple therapy for treatment-resistant methamphetamine use disorder: a case series","volume":"18","author":"Shariatzadeh N","year":"2026","unstructured":"Shariatzadeh N, Wakhlu S: Naltrexone\/bupropion\/mirtazapine triple therapy for treatment-resistant methamphetamine use disorder: a case series. Cureus 2026; 18:e102744","journal-title":"Cureus"},{"key":"e_1_3_2_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2024.111129"},{"key":"e_1_3_2_108_2","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000001517"},{"key":"e_1_3_2_109_2","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13229"},{"key":"e_1_3_2_110_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agad078"},{"key":"e_1_3_2_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2024.07.007"},{"key":"e_1_3_2_112_2","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13386"},{"key":"e_1_3_2_113_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.2096"},{"key":"e_1_3_2_114_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2026.0972"},{"key":"e_1_3_2_115_2","doi-asserted-by":"publisher","DOI":"10.1080\/10550887.2023.2195777"},{"key":"e_1_3_2_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2025.116446"},{"key":"e_1_3_2_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2022.109606"},{"key":"e_1_3_2_118_2","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2025.2535559"},{"key":"e_1_3_2_119_2","first-page":"e38498","article-title":"Ketamine treatment for alcohol use disorder: a systematic review","volume":"15","author":"Kelson M","year":"2023","unstructured":"Kelson M, Burnett JM, Matthews A, et al: Ketamine treatment for alcohol use disorder: a systematic review. Cureus 2023; 15:e38498","journal-title":"Cureus"},{"key":"e_1_3_2_120_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2021.21030277"},{"key":"e_1_3_2_121_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.josat.2025.209705"},{"key":"e_1_3_2_122_2","doi-asserted-by":"publisher","DOI":"10.1080\/10550887.2025.2450129"},{"key":"e_1_3_2_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.08.009"},{"key":"e_1_3_2_124_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.39"},{"key":"e_1_3_2_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.01.005"},{"key":"e_1_3_2_126_2","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2020.1808982"},{"key":"e_1_3_2_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2024.09.008"},{"key":"e_1_3_2_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.06.007"},{"key":"e_1_3_2_129_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-018-9393-5"},{"key":"e_1_3_2_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2008.06.004"},{"key":"e_1_3_2_131_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00598"},{"key":"e_1_3_2_132_2","first-page":"111","article-title":"Transcranial direct current stimulation in the treatment of alcohol, tobacco and opioid use disorder in clinical studies","volume":"84","author":"\u00c7abuk BM","year":"2024","unstructured":"\u00c7abuk BM, Guleken Z: Transcranial direct current stimulation in the treatment of alcohol, tobacco and opioid use disorder in clinical studies. Acta Neurobiol Exp 2024; 84:111\u2013127","journal-title":"Acta Neurobiol Exp"}],"container-title":["American Journal of Psychiatry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:23:03Z","timestamp":1788236583000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20260362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":131,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1176\/appi.ajp.20260362"],"URL":"https:\/\/doi.org\/10.1176\/appi.ajp.20260362","relation":{},"ISSN":["0002-953X","1535-7228"],"issn-type":[{"value":"0002-953X","type":"print"},{"value":"1535-7228","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}