{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:54:02Z","timestamp":1776228842266,"version":"3.50.1"},"reference-count":36,"publisher":"American Psychiatric Association Publishing","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1176\/appi.focus.26024111","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:00:19Z","timestamp":1776225619000},"page":"212-222","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Safety and Maintenance of Response With Esketamine Nasal Spray in Participants With Treatment-Resistant Depression: Interim Results of the SUSTAIN-3 Study"],"prefix":"10.1176","volume":"24","author":[{"given":"Naim","family":"Zaki","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Janssen Research &amp; Development, LLC, Titusville, NJ, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li (Nancy)","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Janssen Research &amp; Development, LLC, Titusville, NJ, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanne","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Clinical Biostatistics, Janssen Research &amp; Development, LLC, Titusville, NJ, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Janssen Research &amp; Development, LLC, Titusville, NJ, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne C.","family":"Drevets","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Janssen Research &amp; Development, LLC, San Diego, CA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall L.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Janssen Research &amp; Development, LLC, Titusville, NJ, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-8829","authenticated-orcid":false,"given":"Gerard","family":"Sanacora","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel T.","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanina","family":"Popova","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Janssen Research &amp; Development Belgium, Beerse, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Jing","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Janssen Research &amp; Development, LLC, Titusville, NJ, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"230","reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(03)00231-2"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.20m13699"},{"key":"e_1_3_7_4_2","volume-title":"Practice Guideline for the Treatment of Patients with Major Depressive Disorder","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association. Practice Guideline for the Treatment of Patients with Major Depressive Disorder, 3rd ed. American Psychiatric Association: Washington, DC; 2013. https:\/\/psychiatryonline.org\/pb\/assets\/raw\/sitewide\/practice_guidelines\/guidelines\/mdd.pdf. Accessed 18 September 2022.","edition":"3"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyy009"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-018-1920-7"},{"key":"e_1_3_7_8_2","unstructured":"SpravatoTM (esketamine) nasal spray Prescribing Information. \u00a9 2020 Janssen Pharmaceutical Companies."},{"key":"e_1_3_7_9_2","unstructured":"Spravato (esketamine) Summary of Product Characteristics. https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/spravato-epar-product-information_en.pdf. Accessed 18 September 2022."},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.3739"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2019.1189"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyz039"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2019.10.008"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19020172"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19m12891"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.7.1035"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acp010"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2008.03.002"},{"key":"e_1_3_7_19_2","volume-title":"Hopkins Verbal Learning Test - Revised, Professional Manual","author":"Brandt J","year":"2007","unstructured":"Brandt J, Benedict RHB. Hopkins Verbal Learning Test - Revised, Professional Manual. PAR: Lutz, FL; 2007."},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.134.4.382"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.2190\/T8EM-C8YH-373N-1UWD"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.18.1737"},{"key":"e_1_3_7_23_2","volume-title":"ECDEU Assessment Manual for Psychopharmacology","author":"Guy W.","year":"1976","unstructured":"Guy W. ECDEU Assessment Manual for Psychopharmacology. US Department of Health, Education, and Welfare: Rockville, MD; 1976."},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.201900295"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e3282f2b4d6"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2707"},{"key":"e_1_3_7_27_2","volume-title":"Optum\u00ae ClinformaticsTM Extended Data Mart","year":"2021","unstructured":"Optum\u00ae ClinformaticsTM Extended Data Mart, Eden Praire, MN; optum.com\/life-sciences-solutions. August, 2021."},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.4602"},{"key":"e_1_3_7_29_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2010.09050627"},{"key":"e_1_3_7_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(99)00004-X"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.06.030"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2012.724745"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2018.04.016"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19070688"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1017\/S2045796020000268"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.184"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1037\/a0032650"}],"container-title":["Focus"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:01:44Z","timestamp":1776225704000},"score":1,"resource":{"primary":{"URL":"https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.focus.26024111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1176\/appi.focus.26024111"],"URL":"https:\/\/doi.org\/10.1176\/appi.focus.26024111","relation":{},"ISSN":["1541-4094","1541-4108"],"issn-type":[{"value":"1541-4094","type":"print"},{"value":"1541-4108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}