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This study examines the characteristics of treatment options during the first month of enrollment among depressed youth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data for 646 depressed youth were extracted from the Texas Youth Depression and Suicide Research Network study. Participants' treatments during the first month were categorized as no treatment (NT), psychotherapy only (THER), pharmacotherapy only (MED), or a combination of psychotherapy and pharmacotherapy (COMB). Sociodemographic and clinical features were compared across these treatment types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>7% were on NT, 5% on THER, 35% on MED, and 53% on COMB. The MED group was more likely to have low income compared to the COMB group. Compared to the MED group, COMB treatment had higher depression severity and suicidality. The NT group showed higher rates of social risk compared to the group with COMB. Treatment groups did not differ significantly in sex or race. When treatment preferences were examined, 40% of youth on MED expressed a preference for COMB treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment options vary with demographic characteristics, depression severity, suicidality, and high\u2010risk social factors. The finding that youth on MED are more likely to have low income compared to COMB treatment, despite a preference for COMB treatment among many, may suggest a potential barrier to accessing comprehensive treatment options.<\/jats:p><\/jats:sec><jats:sec><jats:title>Relevance to Clinical Practice<\/jats:title><jats:p>Findings highlight the need to address barriers to combination treatment, which is preferred by youth and caregivers for managing depression.<\/jats:p><\/jats:sec>","DOI":"10.1176\/appi.prcp.20240117","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T11:07:59Z","timestamp":1742814479000},"page":"128-138","source":"Crossref","is-referenced-by-count":0,"title":["Examining Treatment Options in Youth With Major Depressive Disorder: Observations From the TX\u2010YDSRN Registry Study"],"prefix":"10.1176","volume":"7","author":[{"given":"Emine Rabia","family":"Ayvaci","sequence":"first","affiliation":[{"name":"Center for Depression Research and Clinical Care Peter O\u2019Donnell Jr. Brain Institute and Department of Psychiatry University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Children's Health Children's Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karabi","family":"Nandy","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care Peter O\u2019Donnell Jr. Brain Institute and Department of Psychiatry University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Peter O\u2019Donnell Jr. School of Public Health University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Becker","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care Peter O\u2019Donnell Jr. Brain Institute and Department of Psychiatry University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Stone","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care Peter O\u2019Donnell Jr. Brain Institute and Department of Psychiatry University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Children's Health Children's Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abu","family":"Minhajuddin","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care Peter O\u2019Donnell Jr. Brain Institute and Department of Psychiatry University of Texas Southwestern Medical Center  Dallas Texas USA"},{"name":"Peter O\u2019Donnell Jr. School of Public Health University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holli","family":"Slater","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care Peter O\u2019Donnell Jr. Brain Institute and Department of Psychiatry University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynnel C.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Center for Depression Research and Clinical Care Peter O\u2019Donnell Jr. Brain Institute and Department of Psychiatry University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M.","family":"Wakefield","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Texas Tech University Health Science Center  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Storch","sequence":"additional","affiliation":[{"name":"Menninger Department of Psychiatry and Behavioral Sciences Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph C.","family":"Blader","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center at San Antonio  San Antonio Texas USA"},{"name":"Louis A. 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