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The spectrum of disease is quite variable, ranging from relatively mild disease to severe, aggressive manifestations that result in frequent hospitalizations, multiple surgeries, and poor quality of life. Despite significant recent advances in surgical and medical management, treatment remains challenging and frequently requires a multidisciplinary medical-surgical approach. The goal of this article is to review the current literature regarding the work-up, treatment, and future directions of therapy. Crucial features of effective management include the precise identification of manifestations, control of sepsis, limiting rectal inflammation, frequently with use of antitumor necrosis factor agents, and avoidance of extensive surgery.<\/jats:p>","DOI":"10.1177\/0003134820956331","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T06:38:49Z","timestamp":1608359929000},"page":"1361-1367","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Modern Management of Perianal Crohn\u2019s Disease: A Review"],"prefix":"10.1177","volume":"87","author":[{"given":"Jennifer L.","family":"Williams","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Colorectal Surgery, Emory University, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia O.","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Department of Surgery, 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