{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:25:23Z","timestamp":1777447523624,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T00:00:00Z","timestamp":1609200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastrointestinal (GI) perforation is a risk factor for mortality in very low birth weight (VLBW) infants. Little data exist regarding pretreatment factors and patient characteristics known to independently correlate with risk of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective review of all VLBW infants who sustained GI perforation between 2011 and 2018 was conducted. Birth, laboratory, and disease-related factors of infants who died were compared to those who survived.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>42 VLBW infants who sustained GI perforations were identified. Eleven (26.19%) died. There were no significant differences in birth-related factors, hematological lab levels at diagnosis, presence of pneumatosis, or bacteremia. Portal venous gas ( P = .03), severe metabolic acidosis ( P &lt; .01), and elevated lactate at diagnosis ( P &lt; .01) were statistically more likely to occur among infants who died.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Portal venous gas, severe metabolic acidosis, and elevated lactate were associated with an increased risk of mortality among VLBW infants who develop a GI perforation. Further research is required to better identify risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003134820956928","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T23:26:04Z","timestamp":1609284364000},"page":"1463-1467","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of Mortality Among Very Low Birth Weight Infants With Gastrointestinal Perforation"],"prefix":"10.1177","volume":"87","author":[{"given":"Marina L.","family":"Reppucci","sequence":"first","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Icahn School of Medicine Mount Sinai, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliza H.","family":"Hersh","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Icahn School of Medicine Mount Sinai, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prerna","family":"Khetan","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Icahn School of Medicine Mount Sinai, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian A.","family":"Coakley","sequence":"additional","affiliation":[{"name":"Division of General Surgery, Department of Surgery, Icahn School of Medicine Mount Sinai, USA"},{"name":"Division of Pediatric Surgery, Department of Surgery, Icahn School of Medicine Mount Sinai, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,29]]},"reference":[{"issue":"13","key":"bibr1-0003134820956928","first-page":"1","volume":"68","author":"Martin JA","year":"2019","journal-title":"Natl Vital Stat Rep"},{"issue":"312","key":"bibr2-0003134820956928","first-page":"1","author":"Martin JA","year":"2018","journal-title":"NCHS Data Brief"},{"key":"bibr3-0003134820956928","unstructured":"Centers for Disease Control and Prevention. 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