{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:47:00Z","timestamp":1787060820151,"version":"build-2736575974"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Appendiceal cancer (AC) is a rare malignancy usually diagnosed incidentally after appendectomy. Risk factors for AC are poorly understood. We sought to provide a descriptive analysis for patients with AC discovered after appendectomy for acute appendicitis (AA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The 2016-2017 American College of Surgeons-National Surgical Quality Improvement Program Procedure-Targeted Appendectomy database was queried for adult patients who underwent appendectomy for image-suspected AA. Patients with pathology consistent with AA were compared to patients found to have AC. A multivariable logistic regression model was used for analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From 21\u00a0058 patients, 203 (1.0%) were found to have AC on pathology. Compared to patients with AA, patients with AC were older (median, 48 vs. 40\u00a0years old, P &lt; .001). The AA group had a similar rate of perforated appendix compared to the AC group (16.3% vs. 13.4% P = .32). After adjusting for covariates, associated risk factors for AC were: age \u226565\u00a0years old (odds ratio (OR) 2.25, 1.5-3.38, P &lt; .001), absence of leukocytosis (OR 1.58, 1.16-2.17, P = .004), and operative time \u22651\u00a0hour (OR 1.57, 1.14-2.16, P = .006). Gender, race, and history of smoking were not independent associated risk factors for AC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of AC after appendectomy for suspected AA is approximately 1% in a large national analysis. These factors may be used to help identify patients at higher risk for AC after appendectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003134820960077","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T13:44:26Z","timestamp":1607607866000},"page":"994-998","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk Factors for Appendiceal Cancer After Appendectomy"],"prefix":"10.1177","volume":"87","author":[{"given":"Stephen J.","family":"Stopenski","sequence":"first","affiliation":[{"name":"Department of Surgery, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areg","family":"Grigorian","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Carmichael","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Mills","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Brady","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Dolich","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Kuza","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninh T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffry","family":"Nahmias","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of California, Orange, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"bibr1-0003134820960077","volume-title":"Surgeries in Hospital-Based Ambulatory Surgery and Hospital Inpatient Settings Statistical Brief #223. 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