{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:26:11Z","timestamp":1777447571069,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:00:00Z","timestamp":1608336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100005440","name":"Center for Scientific Review","doi-asserted-by":"publisher","award":["NIH-RO1 GM115353"],"award-info":[{"award-number":["NIH-RO1 GM115353"]}],"id":[{"id":"10.13039\/100005440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ventilator-associated pneumonia is poorly understood in trauma. Ventilated trauma patients can develop bacterial burden without symptoms; the factors that influence this are unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Injured adults ventilated for &gt; 2\u00a0days were enrolled. Mini-bronchoalveolar lavage was performed for 14\u00a0days or until extubation. Semi-quantitative cultures were blinded from clinicians. All cultures with &gt; 104 colony forming units (CFU) were assessed for antibiotic exposure (ABXE) and spectrum of coverage. mBAL CFU was assessed daily.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>60 patients were ventilated for 9\u00a0days (median). There were 75 with &gt; 104 CFU. 46 had &gt; 104 CFU and no ABXE on the sample day. 74% had clearance or a decrease (CoD) in CFU without ABXE. 29 had &gt; 104 CFU and ABXE on the sample day. 19 had ABXE with pathogen coverage. 84% had CoD in CFU. 10 had ABXE with no spectrum of coverage. 1\/10 had increased CFU and the remaining 9\/10 CoD in CFU. The three groups were not statistically different on chi-squared analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clearance of pathogens on surveillance cultures was unaffected by ABXE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003134820966281","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T06:34:38Z","timestamp":1608359678000},"page":"1347-1351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Antibiotic Exposure Is Not Associated With Clearance of Bronchoalveolar Growth: Results From a Prospective Ventilator-Associated Pneumonia Study"],"prefix":"10.1177","volume":"87","author":[{"given":"Richard D.","family":"Betzold","sequence":"first","affiliation":[{"name":"R Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley M.","family":"Dennis","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth A.","family":"Bellister","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher A.","family":"Guidry","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery, Department of Surgery, University of Kansas Medical Center, Kansas City, KS, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar D.","family":"Guillamondegui","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wonder","family":"Drake","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Addison K.","family":"May","sequence":"additional","affiliation":[{"name":"Division of Trauma and Acute Care Surgery, Carolinas Medical Center\/Atrium Health, Charlotte, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,19]]},"reference":[{"key":"bibr1-0003134820966281","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.2.439"},{"key":"bibr2-0003134820966281","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2007.04.001"},{"key":"bibr3-0003134820966281","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16226"},{"key":"bibr4-0003134820966281","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.08.05"},{"key":"bibr5-0003134820966281","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2017.199"},{"key":"bibr6-0003134820966281","first-page":"932","volume":"50","author":"Park DR","year":"2005","journal-title":"Respir 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