{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:44:15Z","timestamp":1791337455117,"version":"4.3.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Timing to start of chemoprophylaxis for venous thromboembolism (VTE) in patients with traumatic brain injury (TBI) remains controversial. We hypothesize that early administration is not associated with increased intracranial hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study of adult patients with TBI following blunt injury was performed. Patients with penetrating brain injury, any moderate\/severe organ injury other than the brain, need for craniotomy\/craniectomy, death within 24\u00a0hours of admission, or progression of bleed on 6\u00a0hour follow-up head computed tomography scan were excluded. Patients were divided into early (\u226424\u00a0hours) and late (&gt;24\u00a0hours) cohorts based on time to initiation of chemoprophylaxis. Progression of bleed was the primary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>264 patients were enrolled, 40% of whom were in the early cohort. The average time to VTE prophylaxis initiation was 17\u00a0hours and 47\u00a0hours in the early and late groups, respectively ( P &lt; .0001). There was no difference in progression of bleed (5.6% vs. 7%, P = .67), craniectomy\/-craniotomy rate (1.9% vs. 2.5%, P = .81), or VTE rate (0% vs. 2.5%, P = .1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early chemoprophylaxis is not associated with progression of hemorrhage or need for neurosurgical intervention in patients with TBI and a stable head CT 7\u00a0hours following injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0003134820983171","type":"journal-article","created":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T08:58:51Z","timestamp":1611737931000},"page":"187-193","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":24,"title":["Early Chemoprophylaxis Against Venous Thromboembolism in Patients With Traumatic Brain Injury"],"prefix":"10.1177","volume":"88","author":[{"given":"Lisbi","family":"Rivas","sequence":"first","affiliation":[{"name":"Center for Trauma and Critical Care, Department of Surgery, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vella","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Traumatology, Surgical Critical Care, and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Surgery at the University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Ju","sequence":"additional","affiliation":[{"name":"Center for Trauma and Critical Care, Department of Surgery, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Fernandez-Moure","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Traumatology, Surgical Critical Care, and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Surgery at Duke Medical Center, University of Pennsylvania Perelman School of Medicine, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Sparks","sequence":"additional","affiliation":[{"name":"Center for Trauma and Critical Care, Department of Surgery, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Seamon","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Traumatology, Surgical Critical Care, and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Sarani","sequence":"additional","affiliation":[{"name":"Center for Trauma and Critical Care, Department of Surgery, George Washington University, Washington, DC, 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