{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:18:35Z","timestamp":1778948315281,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Abdominal wall reconstruction in high-risk and contaminated cases remains a challenging surgical dilemma. We report long-term clinical outcomes for a rifampin-\/minocycline-coated acellular dermal graft (XenMatrix\u2122 AB) in complex abdominal wall reconstruction for patients with a prior open abdomen or contaminated wounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing abdominal wall reconstruction at our institution at high risk for surgical site occurrence and reconstructed with XenMatrix\u2122 AB with intent-to-treat between 2014 and 2017 were included. Demographics, operative characteristics, and outcomes were collected. The primary outcome was hernia recurrence. The secondary outcomes included length of stay, surgical site occurrence, readmission, morbidity, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty-two patients underwent abdominal wall reconstruction using XenMatrix\u2122 AB during the study period. Two patients died while inpatient from progression of their comorbid diseases and were excluded. Sixty percent of patients had an open abdomen at the time of repair. All patients were from modified Ventral Hernia Working Group class 2 or 3. There were a total of four 30-day infectious complications including superficial cellulitis\/fat necrosis (15%) and one intraperitoneal abscess (5%). No patients required reoperation or graft excision. Median clinical follow-up was 38.2\u00a0months with a mean of 35.2 +\/\u2212 18.5\u00a0months. Two asymptomatic recurrences and one symptomatic recurrence were noted during this period with one planning for elective repair of an eventration. Follow-up was extended by phone interview which identified no additional recurrences at a median of 45.5 and mean of 50.5 +\/\u221212.7\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We present long-term outcomes for patients with high-risk and contaminated wounds who underwent abdominal wall reconstruction reinforced with XenMatrix\u2122 AB to achieve early, permanent abdominal closure. Acceptable outcomes were noted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348211023392","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T16:29:54Z","timestamp":1622305794000},"page":"1988-1995","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Long-Term Clinical Outcomes of an Antibiotic-Coated Non\u2013Cross-linked Porcine Acellular Dermal Graft for Abdominal Wall Reconstruction for High-Risk and Contaminated Wounds"],"prefix":"10.1177","volume":"88","author":[{"given":"Jordan","family":"Robinson","sequence":"first","affiliation":[{"name":"Division of Hepatopancreaticobiliary Surgery, Department of Surgery, Atrium Health-Carolinas Medical Center, Charlotte, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse K.","family":"Sulzer","sequence":"additional","affiliation":[{"name":"Division of Hepatopancreaticobiliary Surgery, Department of Surgery, Atrium Health-Carolinas Medical Center, Charlotte, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Motz","sequence":"additional","affiliation":[{"name":"Division of Hepatopancreaticobiliary Surgery, Department of Surgery, Atrium Health-Carolinas Medical Center, Charlotte, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin H.","family":"Baker","sequence":"additional","affiliation":[{"name":"Division of Hepatopancreaticobiliary Surgery, Department of Surgery, Atrium Health-Carolinas Medical Center, Charlotte, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John B.","family":"Martinie","sequence":"additional","affiliation":[{"name":"Division of Hepatopancreaticobiliary Surgery, Department of Surgery, Atrium Health-Carolinas Medical Center, Charlotte, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionisios","family":"Vrochides","sequence":"additional","affiliation":[{"name":"Division of Hepatopancreaticobiliary Surgery, Department of Surgery, Atrium Health-Carolinas Medical Center, Charlotte, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Iannitti","sequence":"additional","affiliation":[{"name":"Division of Hepatopancreaticobiliary Surgery, Department of Surgery, Atrium Health-Carolinas Medical Center, Charlotte, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"bibr1-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60459-7"},{"key":"bibr2-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000124291.09032.bf"},{"key":"bibr3-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000000371"},{"key":"bibr4-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000141193.08524.e7"},{"key":"bibr5-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2011.033"},{"key":"bibr6-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-007-0286-4"},{"key":"bibr7-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.06.041"},{"key":"bibr8-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.10.013"},{"key":"bibr9-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1266-5"},{"key":"bibr10-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1177\/000313481708300845"},{"key":"bibr11-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004871"},{"key":"bibr12-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001831"},{"key":"bibr13-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200211000-00007"},{"key":"bibr14-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199406000-00007"},{"key":"bibr15-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001314"},{"key":"bibr16-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.08.003"},{"key":"bibr17-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1177\/1553350616656280"},{"key":"bibr18-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.10.010"},{"key":"bibr19-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-019-01917-9"},{"key":"bibr20-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.03.017"},{"key":"bibr21-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2016.05.022"},{"key":"bibr22-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.01.008"},{"key":"bibr23-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2012.08.012"},{"key":"bibr24-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-019-02000-z"},{"key":"bibr25-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2015.04.026"},{"key":"bibr26-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-020-02124-7"},{"key":"bibr27-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-020-01881-4"},{"key":"bibr28-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-07435-5"},{"key":"bibr29-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2019.12.008"},{"key":"bibr30-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004062"},{"key":"bibr31-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004862"},{"key":"bibr32-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2010.03.065"},{"key":"bibr33-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000445056.92945.a8"},{"key":"bibr34-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.10.011"},{"key":"bibr35-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2015.5234"},{"key":"bibr36-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000445056.92945.a8"},{"key":"bibr37-00031348211023392","doi-asserted-by":"publisher","DOI":"10.1177\/000313481408000104"},{"key":"bibr38-00031348211023392","doi-asserted-by":"publisher","DOI":"10.3352\/jeehp.2013.10.12"}],"container-title":["The 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