{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:36:35Z","timestamp":1794015395008,"version":"4.8.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To review the effectiveness of noninvasive multitarget stool DNA testing as a screening test for colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of patients referred to 2 high volume outpatient procedural centers for colonoscopy for positive Cologuard test. Positive findings for colorectal cancer based on pathologic findings and also advanced adenomas were recorded. Positive predictive value (PPV) was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 1585 patients evaluated and referred for colonoscopy from January 1, 2018 to November 1, 2019, for ICD-10 codes R19.5 (other fecal abnormalities) and K92.1 (melena), 84 were referred for a positive Cologuard test. Out of the 84, 6 were excluded based on family history of colon cancer in first degree relative or personal history of inflammatory bowel disease. Of the remaining 78 patients, 1 patient (1.3%) had colorectal cancer and 5 (6.4%) had advanced adenomas (&gt;1\u00a0cm size, high grade dysplasia or villous). Postive predictive value for colorectal cancer was 1.3% and for precancerous lesions plus colorectal cancer was 7.7%. A total of 53 (68.0%) patients had either totally normal colonoscopy or hyperplastic polyps. Out of the 78 individuals in our study, 70 (89.7%) had normal findings, hyperplastic polyps, or non-advanced adenomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multitarget stool DNA testing carries an unacceptably low PPV to be utilized as a screening test for colorectal cancer. The study fails to detect both adenomas and colon cancer at a higher rate than screening colonoscopy in selected studies. The advantage of being noninvasive has been noted to increase colorectal cancer screening in otherwise non-compliant Medicare patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348211031844","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:31:13Z","timestamp":1626643873000},"page":"603-606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Retrospective Review of Multitarget Stool DNA as a Screening Test for Colorectal Cancer"],"prefix":"10.1177","volume":"89","author":[{"given":"Thomas K.","family":"Kleinschmidt","sequence":"first","affiliation":[{"name":"Brookwood Baptist Health Systems, Birmingham, AL, USA"},{"name":"St Vincent\u2019s Hospital, Birmingham, AL, USA"},{"name":"Grandview Medical Center, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"Clements","sequence":"additional","affiliation":[{"name":"Brookwood Baptist Health Systems, Birmingham, AL, USA"},{"name":"Grandview Medical Center, Birmingham, AL, USA"},{"name":"Edward Via College of Osteopathic Medicine, Auburn, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Parker","sequence":"additional","affiliation":[{"name":"Brookwood Baptist Health Systems, Birmingham, AL, USA"},{"name":"St Vincent\u2019s Hospital, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Scarcliff","sequence":"additional","affiliation":[{"name":"Brookwood Baptist Health Systems, Birmingham, AL, USA"},{"name":"St Vincent\u2019s Hospital, Birmingham, AL, USA"},{"name":"Grandview Medical Center, Birmingham, AL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,18]]},"reference":[{"key":"bibr1-00031348211031844","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21601"},{"key":"bibr2-00031348211031844","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6608a1"},{"key":"bibr3-00031348211031844","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21457"},{"key":"bibr4-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5989"},{"key":"bibr5-00031348211031844","doi-asserted-by":"publisher","DOI":"10.15212\/FMCH.2015.0125"},{"key":"bibr6-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00390.x"},{"key":"bibr7-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907667"},{"key":"bibr8-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2000.108480"},{"key":"bibr9-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00673.x"},{"key":"bibr10-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.05.032"},{"key":"bibr11-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1311194"},{"key":"bibr12-00031348211031844","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i3.464"},{"key":"bibr13-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1100370"},{"key":"bibr14-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12181"},{"key":"bibr15-00031348211031844","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37401-3"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348211031844","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348211031844","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348211031844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:36:06Z","timestamp":1777379766000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348211031844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,18]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1177\/00031348211031844"],"URL":"https:\/\/doi.org\/10.1177\/00031348211031844","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,18]]}}}