{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:24:56Z","timestamp":1777447496643,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC) is associated with significant operative time, hospital resources, and morbidity. We examine factors associated with hospital length of stay (LOS) and early overall survival (OS) after CRS\/HIPEC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Patients who underwent CRS\/HIPEC were evaluated for factors associated with LOS. Institutional learning curve influence was addressed by comparing early vs late cohorts. Variables with P &lt; .200 after univariate analysis were considered for inclusion in multivariate linear regression modeling. Independent factors associated with OS were evaluated using the Kaplan-Meier method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy patients underwent CRS\/HIPEC (mean age 52.3\u00a0years, 64.3% female, and 68.6% Caucasian). Presence of any surgical complication was found in 26 (37.1%), 28 (40%) remained intubated postoperatively, and the mean Peritoneal Carcinomatosis Index (PCI) score was 14.4 ([Formula: see text]10.4). Mean intensive care unit and hospital LOS were 2.9\u00a0days ([Formula: see text]2.3) and 9.6\u00a0days ([Formula: see text]3.6), respectively. After adjusting for covariates, only shorter time to postoperative ambulation (regression coefficient .92, P = .001) and early extubation (regression coefficient \u22121.90, P = .018) were associated with decreased hospital LOS on multivariate analysis. Immediate postoperative extubation conferred an independent early survival benefit on Kaplan-Meier analysis (mean OS 714.8 vs 473.4\u00a0days, P = .010). There was no difference in hospital LOS or OS between early and late cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early postoperative extubation and shorter time to ambulation are associated with decreased hospital LOS. Moreover, CRS\/HIPEC patients extubated immediately postoperatively have an early survival benefit. Every effort should be made to achieve early postoperative extubation and mobilization in CRS\/HIPEC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348211050588","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:42:36Z","timestamp":1641861756000},"page":"887-893","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Early Postoperative Extubation is Associated with Shorter Hospitalization and Improved Short-Term Survival in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy"],"prefix":"10.1177","volume":"88","author":[{"given":"Leah E.","family":"Hendrick","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William P.","family":"Hewgley","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Douthitt","sequence":"additional","affiliation":[{"name":"Memphis Anesthesia Group, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paxton V.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan S.","family":"Glazer","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W.","family":"Behrman","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremiah L.","family":"Deneve","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"bibr1-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890115)63:2<364::AID-CNCR2820630228>3.0.CO;2-V"},{"key":"bibr2-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.187"},{"key":"bibr3-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9966-2"},{"key":"bibr4-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3358-y"},{"key":"bibr5-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708618"},{"key":"bibr6-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1159\/000011847"},{"key":"bibr7-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05380.x"},{"key":"bibr8-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0253-z"},{"key":"bibr9-00031348211050588","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2016078"},{"key":"bibr10-00031348211050588","doi-asserted-by":"publisher","DOI":"10.9738\/INTSURG-D-14-00138.1"},{"key":"bibr11-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-1247-5_23"},{"key":"bibr12-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916281"},{"key":"bibr13-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"bibr14-00031348211050588","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_39_18"},{"key":"bibr15-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5692-3"},{"key":"bibr16-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4963-8"},{"key":"bibr17-00031348211050588","doi-asserted-by":"publisher","DOI":"10.4103\/ija.IJA_480_20"},{"key":"bibr18-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09476-5"},{"key":"bibr19-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2016.06.390"},{"key":"bibr20-00031348211050588","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-4111-x"}],"container-title":["The 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