{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:01:10Z","timestamp":1780484470259,"version":"3.54.1"},"reference-count":4,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>Multiple gastrointestinal stromal tumors (GISTs) of the small intestine is an uncommon finding but can be a marker for underlying neurofibromatosis type 1 (NF1). We present the case of the 38-year-old male without prior NF1 diagnosis who presented with a small bowel obstruction. His physical exam was notable for cutaneous nodules and caf\u00e9-au-lait spots. He progressed to peritonitis and underwent an exploratory laparotomy, which revealed a 6-cm hemorrhagic mass along the antimesenteric border of the jejunum, causing obstruction and perforation. Pathology was consistent with GISTs. NF1-associated GISTs differ from wild-type GISTs in that they are unlikely to have C-KIT and PDGFRA mutations and therefore do not respond to imatinib. Treatment is largely limited to surgical resection; however, there is evidence that MEK inhibitors may prove an additional treatment strategy.<\/jats:p>","DOI":"10.1177\/00031348221083934","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T04:36:35Z","timestamp":1647146195000},"page":"1541-1542","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Neurofibromatosis-associated Gastrointestinal Stromal Tumor Causing Small Bowel Obstruction"],"prefix":"10.1177","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8371-1822","authenticated-orcid":false,"given":"H. David","family":"Schaeffer","sequence":"first","affiliation":[{"name":"Department of Surgery, Geisinger Commonwealth School of Medicine, Danville, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"UPMC Carlisle Bariatric Surgery Associates, Carlisle, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Factor","sequence":"additional","affiliation":[{"name":"Department of Surgery, Geisinger Commonwealth School of Medicine, Danville, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,13]]},"reference":[{"key":"bibr1-00031348221083934","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.140"},{"issue":"7","key":"bibr2-00031348221083934","first-page":"101","volume":"91","author":"Foiadelli T","year":"2020","journal-title":"Acta Biomed"},{"key":"bibr3-00031348221083934","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000159775.77912.15"},{"issue":"1","key":"bibr4-00031348221083934","first-page":"i124","volume":"2","author":"Dare AJ","year":"2020","journal-title":"Neurooncol Adv"}],"container-title":["The American Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348221083934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348221083934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348221083934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:36:19Z","timestamp":1777379779000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/00031348221083934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,13]]},"references-count":4,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1177\/00031348221083934"],"URL":"https:\/\/doi.org\/10.1177\/00031348221083934","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,13]]}}}