{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:33:36Z","timestamp":1777448016312,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The 5-year overall survival (OS) rate for patients with metastatic gastric cancer (mGC) is 5.3%. Surgery for mGC is controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified all mGC patients who received chemotherapy using the National Cancer Database (2004-2015). Patients were grouped according to surgery of: (1) the primary site (PS) only, (2) primary and distant sites (PDS), (3) distant site only (DS), or (4) no surgery (NS). A propensity score adjustment and multivariate regression was used to compare OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 18,772 patients met the inclusion criteria: (1) PS (n = 962, 5.1%), (2) PDS (n = 380, 2.1%), (3) DS (n = 984, 5.2%), and 16,446 NS (87.6%). Surgery was associated with improved OS in the PS and PDS groups (hazard ratios: .489 (95% CI: .376-.636); .583 (95% CI: .420-.811), P &lt; .001) (median OS 15.8 and 15.9 months vs 8.6 for NS patients, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gastrectomy with or without metastasectomy is associated with improved survival in stage IV gastric cancer patients receiving chemotherapy. This warrants further prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348221086800","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T21:24:08Z","timestamp":1654118648000},"page":"2637-2643","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Surgery is Associated With Improved Overall Survival in Patients With Metastatic Gastric Cancer: A National Cancer Database Analysis"],"prefix":"10.1177","volume":"88","author":[{"given":"Stephanie H.","family":"Greco","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua C.","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole G.","family":"Heath","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Lin","sequence":"additional","affiliation":[{"name":"Section of Gastrointestinal Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA"},{"name":"Department of Biostatistics, Rutgers School of Public Health, Piscataway, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor A.","family":"Gall","sequence":"additional","affiliation":[{"name":"Department of Surgery, Community Medical Center, RWJBarnabas Health, Toms River, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miral S.","family":"Grandhi","sequence":"additional","affiliation":[{"name":"Section of Gastrointestinal Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Section of Gastrointestinal Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren R.","family":"Carpizo","sequence":"additional","affiliation":[{"name":"Division of Surgical Oncology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Richard","family":"Alexander","sequence":"additional","affiliation":[{"name":"Section of Gastrointestinal Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell C.","family":"Langan","sequence":"additional","affiliation":[{"name":"Section of Gastrointestinal Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA"},{"name":"Saint Barnabas Medical Center, RWJBarnabas Health, Livingston, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"August","sequence":"additional","affiliation":[{"name":"Department of Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA"},{"name":"Section of Gastrointestinal Surgical Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"bibr1-00031348221086800","unstructured":"SEER Stat Fact Sheets: Stomach cancer. 2017. Available: https:\/\/seer.cancer.gov\/statfacts\/html\/stomach.html"},{"key":"bibr2-00031348221086800","unstructured":"National Comprehensive Cancer Network. Gastric cancer (Version 4.2020). 2020. http:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/gastric.pdf. Accessed March 22."},{"key":"bibr3-00031348221086800","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00553-7"},{"key":"bibr4-00031348221086800","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23633"},{"key":"bibr5-00031348221086800","doi-asserted-by":"publisher","DOI":"10.5230\/jgc.2013.13.4.226"},{"key":"bibr6-00031348221086800","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-017-0742-5"},{"key":"bibr7-00031348221086800","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14027"},{"key":"bibr8-00031348221086800","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23945"},{"key":"bibr9-00031348221086800","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0227"},{"key":"bibr10-00031348221086800","first-page":"CD004064","volume":"8","author":"Wagner AD","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr11-00031348221086800","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29134"},{"key":"bibr12-00031348221086800","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-018-0883-1"},{"key":"bibr13-00031348221086800","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.142.4.387"},{"key":"bibr14-00031348221086800","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000048"},{"key":"bibr15-00031348221086800","doi-asserted-by":"crossref","first-page":"e0182255","DOI":"10.1371\/journal.pone.0182255","volume":"12","author":"Li SC","year":"2017","journal-title":"PLoS One"},{"key":"bibr16-00031348221086800","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23920"}],"container-title":["The American Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348221086800","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348221086800","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348221086800","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:36:36Z","timestamp":1777379796000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/00031348221086800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1177\/00031348221086800"],"URL":"https:\/\/doi.org\/10.1177\/00031348221086800","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]}}}