{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T07:42:46Z","timestamp":1781595766167,"version":"3.54.5"},"reference-count":20,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The State of Texas Emerging Technology Fund"},{"name":"The University of Texas Health Science Center's Center for Translational Injury Research"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Limitations in available donors have dramatically reduced plasma availability over the past several decades, concurrent with increasing demand for some types of plasma. Plasma from female donors who are pregnant or taking oral contraceptives often has a green appearance, which frequently results in these units being discarded. This pilot study aimed to evaluate the hemostatic potential of green compared to standard-color plasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Plasma from twelve blood group-matched female and twelve male donors was obtained from the local blood center. Six of the female and all of the male units of plasma had a normal appearance (STANDARD), while six of the female units were grossly green (GREEN). The hemostatic potential was evaluated by thrombelastography (TEG), calibrated automated thrombogram (CAT), and coagulation factor level measurements. Univariate analysis was performed using Wilcoxon Rank-Sum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GREEN plasma was more procoagulant for all TEG values ( r-value, k-time, angle, mA) when compared to STANDARD plasma. Differences were also observed in coagulation factor levels, with GREEN plasma having higher than STANDARD (factors II; VII, IX; X, XI, Protein S, and plasminogen); conversely, GREEN plasma had a longer lag time in CAT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This pilot study demonstrates that female donors with green plasma have a superior hemostatic profile than standard plasma. GREEN plasma should be further investigated for its safety profile and hemostatic potential, so if it is found to be a safe and functionally non-inferior product, it should be actively re-introduced for transfusion in bleeding patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348221096571","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T16:38:58Z","timestamp":1651077538000},"page":"1970-1975","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Green Plasma Has a Superior Hemostatic Profile Compared With Standard Color Plasma"],"prefix":"10.1177","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1693-4935","authenticated-orcid":false,"given":"Kyle J.","family":"Kalkwarf","sequence":"first","affiliation":[{"name":"Division of Trauma and Acute Care Surgery, Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Cardenas","sequence":"additional","affiliation":[{"name":"Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Wade","sequence":"additional","affiliation":[{"name":"Center for Translational Injury Research, University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan A.","family":"Cotton","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Texas Health Science Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"bibr1-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15604"},{"key":"bibr2-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15715"},{"key":"bibr3-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000641"},{"key":"bibr4-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2017.07.011"},{"key":"bibr5-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12223"},{"key":"bibr6-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.10.037"},{"key":"bibr7-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb1706496"},{"key":"bibr8-00031348221096571","volume-title":"FDA Statement from Director\u2013\u2013Center for Biologics Evaluation and Research (CBER)","author":"Food and Drug Administration","year":"2020"},{"key":"bibr9-00031348221096571","volume-title":"Red Cross Warns of a \u201cStaggering\u201d Drop in Blood Supplies","author":"Flavelle C","year":"2020"},{"key":"bibr10-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.02.014"},{"key":"bibr11-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318148566"},{"key":"bibr12-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009421"},{"issue":"7568","key":"bibr13-00031348221096571","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/S0140-6736(68)90696-X","volume":"292","author":"Tovey L","year":"1968","journal-title":"Lancet"},{"key":"bibr14-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196907242810407"},{"key":"bibr15-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181672668"},{"key":"bibr16-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200208000-00017"},{"key":"bibr17-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318230089e"},{"key":"bibr18-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000153938.77777.26"},{"key":"bibr19-00031348221096571","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:98:1:01"},{"key":"bibr20-00031348221096571","unstructured":"Jones J, Mosher WD, Daniels K. Current contraceptive use in the United States, 2006\u20132010, and changes in patterns of use since 1995, National Health Statistics Reports. https:\/\/www.cdc.gov\/nchs\/data\/nhsr\/nhsr060.pdf. 2012. Accessed January 31, 2022."}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348221096571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348221096571","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348221096571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:37:00Z","timestamp":1777379820000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348221096571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1177\/00031348221096571"],"URL":"https:\/\/doi.org\/10.1177\/00031348221096571","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,27]]}}}