{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:35:57Z","timestamp":1785281757994,"version":"3.55.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T00:00:00Z","timestamp":1652572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To measure total type 1 serum amino-terminal propeptide procollagen (t-P1NP), \u03b2- type 1 cross-linked C-terminal telopeptide collagen (\u03b2-CTX), N-terminal osteocalcin (OC), and 25-(OH)-VD3 levels before parathyroidectomy (PTX) in patients with PHPT, and correlate these measurements with bone mineral density (BMD) changes at 1-year post-PTX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with primary hyperparathyroidism (PHPT) were followed from diagnosis to 12\u00a0months after surgery. Serum levels of calcium, parathyroid hormone (PTH), vitamin 25-(OH)-VD3, OC, \u03b2-CTX, t-P1NP, and BMD were measured before and 1\u00a0year after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One year after PTX, mean BMD increased by 25.7, 27.7, and 33.5% in the lumbar spine (L1-L4), femoral neck (FN), and greater trochanter (GT), respectively. Percent BMD change 1-year post-PTX was significant correlated with preoperative levels of \u03b2-CTX (L1-L4: r = 0.41 , P &lt; 0.0001; FN: r = 0.54 , P = 0.0003; GT: r = 0.46 , P = 0.0029), t-P1NP (L1-L4: r = 0.58 , P &lt; 0.0001; FN: r = 0.73 , P &lt; 0.0001; GT: r = 0.65 , P &lt; 0.0001), 25-(OH)-VD3 (L1-L4: r = \u22120.33 , P = 0.034; FN: r = \u22120.48 , P = 0.002; GT: r = \u22120.52 , P = 0.0007), and OC (L1-L4: r = 0.49 , P = 0.0013; FN: r = 0.55 , P = 0.0002; GT: r = 0.47 , P = 0.002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Preoperative levels of turnover markers and BMD improvements were significantly correlated in patients with PHPT 1 year after PTX.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348221096574","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T19:28:48Z","timestamp":1652902128000},"page":"2450-2454","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Changes in Bone Mineral Density After Parathyroidectomy and Their Relations With Biochemical Markers of Bone Metabolism"],"prefix":"10.1177","volume":"89","author":[{"given":"Qiqi","family":"Xu","sequence":"first","affiliation":[{"name":"General Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Kong","sequence":"additional","affiliation":[{"name":"General Surgery of Beijing Jishuitan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, 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