{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:37:46Z","timestamp":1777448266105,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>While literature widely supports early cholecystectomy for mild gallstone pancreatitis (GSP), this has not been reflected in clinical practice. Early cholecystectomy for GSP with end organ dysfunction remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to evaluate the rate and outcomes of early cholecystectomy (&lt;3\u00a0days from admission) in mild GSP patients with end organ dysfunction (+EOD) and without (\u2013EOD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with GSP without necrosis were identified from 2017 to 2019 NSQIP database and categorized into GSP\u00b1EOD. Coarsened Exact Matching was used to match patients based on preoperative risk factors in each group, and outcomes were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a total of 3104 patients \u2013EOD and 917 +EOD in the aggregate cohort. Early cholecystectomy was performed in 1520 (49.0%) of GSP-EOD and in 407 (44.4%) of GSP+EOD. In the matched cohorts, there were no significant differences in 30-day mortality, morbidity, or reoperation for early cholecystectomy in either group. In GSP-EOD, early cholecystectomy was associated with shorter LOS (2.9 \u00b1 1.5 vs. 5.6 \u00b1 3.0\u00a0days, P &lt; .001), shorter operative time (69.7 \u00b1 34.4 vs. 73.3 \u00b1 36.6\u00a0min, P = .045), and more concurrent biliary procedures (52.1% vs. 35.4%, P &lt; .001). Similarly, early cholecystectomy in GSP+EOD was associated with shorter LOS (3.3 \u00b1 1.8 vs. 6.9 \u00b1 6.6\u00a0days, P &lt; .001), shorter operative time (65.9 \u00b1 32.1 vs. 76.0 \u00b1 40.7, P &lt; .001), and more concurrent biliary procedure (46.0% vs. 34.9%, P = .002).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study supports early cholecystectomy in patients with mild GSP. Even with end organ dysfunction, early cholecystectomy appears to be safe given there is no difference in morbidity and mortality, and the potential benefit of reduced LOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348221109488","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T11:34:29Z","timestamp":1656502469000},"page":"2579-2583","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Early Cholecystectomy in Gallstone Pancreatitis Patients With and Without End Organ Dysfunction: A NQSIP Analysis"],"prefix":"10.1177","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2706-746X","authenticated-orcid":false,"given":"Jessica K.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-9734","authenticated-orcid":false,"given":"Caitlyn","family":"Braschi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian M.","family":"de Virgilio","sequence":"additional","affiliation":[{"name":"Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Ozao-Choy","sequence":"additional","affiliation":[{"name":"Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashkan","family":"Moazzez","sequence":"additional","affiliation":[{"name":"Department of Surgery, Harbor-UCLA Medical Center, Torrance, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"bibr1-00031348221109488","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2014.01.006"},{"key":"bibr2-00031348221109488","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016150097"},{"issue":"3","key":"bibr3-00031348221109488","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/SLA.0000000000003424","volume":"270","author":"Mueck KM","year":"2019","journal-title":"Ann Surg"},{"issue":"6","key":"bibr4-00031348221109488","first-page":"CD005440","author":"Gurusamy KS","year":"2013","journal-title":"Cochrane Database Syst 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