{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:35:22Z","timestamp":1777448122515,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Clinical hypocalcemia (CH) following total thyroidectomy (TT) is a potentially life-threatening condition if left untreated. This study aimed at evaluating the accuracy of parathyroid hormone (PTH) measured in the early morning of the first postoperative day (POD-1) in predicting CH, and determining the cutoff values of PTH that can predict the development of CH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of patients undergoing TT between February 2018 and July 2022. Serum PTH, calcium, and albumin levels were measured on morning (6-8\u00a0AM) of postoperative day one (POD-1), and serum calcium level was measured from POD-2 onwards. We performed ROC curve analysis to determine the accuracy of PTH in predicting postoperative CH, and cutoff values of PTH to predict CH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ninety-one patients, 52 (57.1%) with benign and 39 (42.9%) with malignant goiter were included. The incidence of biochemical, and clinical hypocalcemia was 24.2% and 30.8%, respectively. In our study serum, PTH measured in the early morning of first postoperative day following TT was found to have good accuracy (AUC = .88) in predicting CH. A PTH value of \u226527.15\u00a0pg\/mL was found to have a 96.4% sensitivity in ruling out CH, while a serum PTH value &lt;10.65\u00a0pg\/mL had a specificity of 95.2% in predicting CH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Patients with a serum PTH value of \u226527.15\u00a0pg\/mL can be discharged without any supplements, those with PTH &lt;10.65\u00a0pg\/mL should be started on calcium and calcitriol supplements, while patients having PTH values between 10.65 and 27.15\u00a0pg\/mL should be monitored for the development of signs and\/or symptoms of hypocalcemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348231161664","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T06:49:26Z","timestamp":1677826166000},"page":"5570-5576","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Accuracy of Serum Parathyroid Hormone Measured on the Early Morning of the First Postoperative Day in Predicting Clinically Significant Post-Total Thyroidectomy Hypocalcemia"],"prefix":"10.1177","volume":"89","author":[{"given":"Prashant K.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Patna, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reva S.","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Patna, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Upasna","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Radiology, All India Institute of Medical Sciences, Patna, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mala","family":"Mahto","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, All India Institute of Medical Sciences, Patna, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandan K.","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of General Surgery, All India Institute of Medical Sciences, Patna, 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