{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:35:53Z","timestamp":1777448153087,"version":"3.51.4"},"reference-count":4,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>\n                    Prophylaxis for deep vein thrombosis is a standard of care for most hospitalized patients. This is typically given in the form of chemical prophylaxis by either, unfractionated heparin or low molecular weight heparin. One complication of administration, besides bleeding, is heparin induced thrombocytopenia (HIT). Of patients receiving therapeutic anticoagulation with heparin an estimated, .5%-1% will go on to develop heparin induced thrombocytopenia.\n                    <jats:sup>1<\/jats:sup>\n                    We will present a case of argatroban refractory HIT after a coronary artery bypass grafting resulting in a massive left ventricular thrombus and death. There is a paucity of literature on the topic of argatroban refractory HIT. When it is discussed, the persistent drop of platelets and ongoing thrombosis, despite argatroban therapy, appears to be the hallmark. The treatment being used in these rare cases is intravenous immunoglobulin. Our case sheds light on the existence of this entity and helps consolidate some literature on the topic.\n                  <\/jats:p>","DOI":"10.1177\/00031348231161690","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T07:27:43Z","timestamp":1678865263000},"page":"3574-3575","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A Case of Argatroban Refractory Heparin Induced Thrombocytopenia and Thrombosis"],"prefix":"10.1177","volume":"89","author":[{"given":"Joclyn A.","family":"Seiler","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam Khan","family":"Durrani","sequence":"additional","affiliation":[{"name":"Royal College of Surgeons in Ireland \u2013 Medical University of Bahrain, Busaiteen, Bahrain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mentor","family":"Ahmeti","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA"},{"name":"Department of Surgery, Sanford Medical Center, Fargo, ND, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"bibr1-00031348231161690","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X19898253"},{"key":"bibr2-00031348231161690","doi-asserted-by":"publisher","DOI":"10.1177\/1941874421995377"},{"key":"bibr3-00031348231161690","doi-asserted-by":"publisher","DOI":"10.12691\/ajmcr-7-9-1"},{"key":"bibr4-00031348231161690","doi-asserted-by":"publisher","DOI":"10.55729\/2000-9666.1102"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348231161690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348231161690","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348231161690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:37:06Z","timestamp":1777379826000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/00031348231161690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":4,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1177\/00031348231161690"],"URL":"https:\/\/doi.org\/10.1177\/00031348231161690","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}