{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:41:34Z","timestamp":1777448494884,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:00:00Z","timestamp":1684540800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University Medical Center IRB","award":["IRB# 200789"],"award-info":[{"award-number":["IRB# 200789"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hemorrhaging trauma patients may be disproportionately affected by choice of induction agent during rapid sequence intubation (RSI). Etomidate, ketamine, and propofol are safe in the trauma population-at-large but have not been assessed in patients with ongoing hemorrhage. We hypothesize that in hemorrhaging patients with penetrating injury, propofol deleteriously affects peri-induction hypotension compared to etomidate and ketamine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study. Primary outcome was the effect of induction agent on peri-induction systolic blood pressure. Secondary outcomes were the incidence of peri-induction vasopressor use and quantity of peri-induction blood transfusion requirements. Linear multivariate regression modeling assessed the effect of induction agent on the variables of interest.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>169 patients were included, 146 received propofol and 23 received etomidate or ketamine. Univariate analysis revealed no difference in peri-induction systolic blood pressure (P = .53), peri-induction vasopressor administration (P = .62), or transfusion requirements within the first hour after induction (PRBC P = .24, FFP P = .19, PLT P = .29). Choice of RSI agent did not independently predict peri-induction systolic blood pressure or blood product administration. Rather, only presenting shock index independently predicted peri-induction hypotension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study to directly assess the peri-induction effects of anesthetic induction agent choice in penetrating trauma patients undergoing emergent hemorrhage control surgery. Propofol does not appear to worsen peri-induction hypotension regardless of dose. Patient physiology is most predictive of peri-induction hypotension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348231177932","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T10:05:31Z","timestamp":1684577131000},"page":"731-738","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Propofol on Peri-Induction Hemodynamics and Resuscitation in Operative Penetrating Trauma"],"prefix":"10.1177","volume":"90","author":[{"given":"Jeremy H.","family":"Levin","sequence":"first","affiliation":[{"name":"Indiana University Health Methodist Hospital, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-0830","authenticated-orcid":false,"given":"Marshall W.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Noel","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer R.","family":"Beavers","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robel T.","family":"Beyene","sequence":"additional","affiliation":[{"name":"Division of Acute Care Surgery, Vanderbilt University Medical Center, Nashville, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,20]]},"reference":[{"key":"bibr1-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181b021c5"},{"key":"bibr2-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1177\/000313481808400959"},{"key":"bibr3-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-014-0479-3"},{"key":"bibr4-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60949-1"},{"key":"bibr5-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2016.08.009"},{"key":"bibr6-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000003132"},{"key":"bibr7-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-021-01759-0"},{"key":"bibr8-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.143.1.62"},{"key":"bibr9-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181a92a70"},{"key":"bibr10-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1986.tb12740.x"},{"key":"bibr11-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu232"},{"key":"bibr12-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.10.044"},{"key":"bibr13-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705649"},{"key":"bibr14-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31828fa54e"},{"key":"bibr15-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182287c8d"},{"key":"bibr16-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000753"},{"key":"bibr17-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/60.1.3"},{"key":"bibr18-00031348231177932","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/67.5.618"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348231177932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348231177932","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348231177932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:38:05Z","timestamp":1777379885000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/00031348231177932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,20]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1177\/00031348231177932"],"URL":"https:\/\/doi.org\/10.1177\/00031348231177932","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,20]]}}}