{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:42:58Z","timestamp":1777448578219,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2023,10]]},"abstract":"\n Background<\/jats:title>\n Intraoperative transfusions in vascular patients undergoing major lower limb amputations (LLAs) are associated with worse postoperative outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective study from 2015 to 2020 to identify perioperative factors associated with the need for intraoperative transfusion for patients undergoing below knee or above knee amputations secondary to vascular disease.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 65 patients with major LLAs were identified, 39 (60%) with below knee and 26 (40%) with above knee amputations. There were 15 (23%) patients who were transfused intraoperatively and 50 (77%) who were not. Six (15%) of the below knee patients and 9 (34%) of the above knee patients required intraoperative transfusion. Of the variables studied, only preoperative hemoglobin (8.6 \u00b1 .4 vs 9.9 \u00b1 .2\u00a0g\/dL, P = .01), change in hemoglobin (\u2212.1 \u00b1 .4 vs .8 \u00b1 .2\u00a0g\/dL, P = .01), estimated intraoperative blood loss (416 \u00b1 168 vs 126 \u00b1 14\u00a0mL, P = .04), and operative duration (116 \u00b1 19\u00a0min. vs 89 \u00b1 6\u00a0min, P = .046) were associated with a transfusion requirement with these patients having a longer length of stay (42 [13-76] vs 21 [12-31] days, P = .04) and a higher risk of mortality (33% vs 10%, P = .03).<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n The study is limited by a small sample size from a single institution. However, patients who received an intraoperative transfusion had a lower starting hemoglobin, higher estimated blood loss, required longer hospital stays, and were at a higher risk for post-discharge mortality.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/00031348231183135","type":"journal-article","created":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T02:19:50Z","timestamp":1687486790000},"page":"4195-4199","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Factors Associated With Intraoperative Transfusion in Patients Undergoing Major Lower Limb Amputation"],"prefix":"10.1177","volume":"89","author":[{"given":"Anand V.","family":"Ganapathy","sequence":"first","affiliation":[{"name":"Department of Surgery, Keck Hospital of USC, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliott A.","family":"Orloff","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth R.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Surgery, Keck Hospital of USC, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"bibr1-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2016.01.012"},{"key":"bibr2-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2009.07.021"},{"key":"bibr3-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-020-01857-4"},{"key":"bibr4-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004710"},{"key":"bibr5-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"bibr6-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174526"},{"key":"bibr7-00031348231183135","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0133"},{"key":"bibr8-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.10.106"},{"key":"bibr9-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2010.05.011"},{"key":"bibr10-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2824.2008.00199.x"},{"key":"bibr11-00031348231183135","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60650-9"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348231183135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348231183135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348231183135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:38:15Z","timestamp":1777379895000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/00031348231183135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,21]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1177\/00031348231183135"],"URL":"https:\/\/doi.org\/10.1177\/00031348231183135","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,21]]}}}