{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T03:54:44Z","timestamp":1777694084389,"version":"3.51.4"},"reference-count":4,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>The relationship between the congenital defect of gastroschisis and environmental toxins is poorly understood. We examined gastroschisis incidence, risk factors, and spatial association in a geographic region with known environmental pollution and hazardous waste sites. An observational study of fetal and neonatal gastroschisis diagnosed from 1\/1\/2006 to 12\/31\/2020 was conducted in a southern West Virginia (WV) tertiary care hospital. Emerging hot spot analysis and Ripley\u2019s K-Function examined the spatial relationship between gastroschisis cases and Environmental Protection Agency (EPA) Federal Registry Sites (FRS). A total of 63 gastroschisis cases provided a prevalence rate of 14.6 per 10000 live births. Gastroschisis was associated with younger maternal age, decreased pre-pregnancy BMI, and increased maternal tobacco use. Relative to FRS sites, spatial clusters were identified with emerging hot spot analysis. Observed Ripley K was higher at all measured bands. Results suggest a potential geographic association between gastroschisis cases and EPA-designated hazardous waste sites.<\/jats:p>","DOI":"10.1177\/00031348231192051","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T02:13:42Z","timestamp":1690337622000},"page":"5017-5020","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and Spatial Distribution of Gastroschisis in an Industrial Watershed"],"prefix":"10.1177","volume":"89","author":[{"given":"Jacob","family":"Minor","sequence":"first","affiliation":[{"name":"Department of Surgery, Charleston Area Medical Center, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Charleston Area Medical Center, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krysta","family":"Orminski","sequence":"additional","affiliation":[{"name":"Institute for Academic Medicine, Charleston Area Medical Center, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-7515","authenticated-orcid":false,"given":"Stephanie N.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Institute for Academic Medicine, Charleston Area Medical Center, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-4119","authenticated-orcid":false,"given":"Frank","family":"Annie","sequence":"additional","affiliation":[{"name":"Institute for Academic Medicine, Charleston Area Medical Center, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Robinson","sequence":"additional","affiliation":[{"name":"Charleston Division, West Virginia University, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron C.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Charleston Area Medical Center, Charleston, WV, USA"},{"name":"Charleston Division, West Virginia University, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramanathapura N.","family":"Haricharan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Charleston Area Medical Center, Charleston, WV, USA"},{"name":"Department of Pediatric Surgery, Charleston Area Medical Center, Charleston, WV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"bibr1-00031348231192051","doi-asserted-by":"publisher","DOI":"10.3390\/children7120302"},{"key":"bibr2-00031348231192051","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2014.10.001"},{"key":"bibr3-00031348231192051","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2019.08.011"},{"key":"bibr4-00031348231192051","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2020.110819d"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348231192051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348231192051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348231192051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:38:23Z","timestamp":1777379903000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348231192051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,25]]},"references-count":4,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1177\/00031348231192051"],"URL":"https:\/\/doi.org\/10.1177\/00031348231192051","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,25]]}}}