{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:46:05Z","timestamp":1777448765453,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies evaluating whether recent cholecystectomy is associated with a pancreas cancer diagnosis are limited. We aimed to examine if cholecystectomy was performed more frequently in the year prior to cancer diagnosis than would be expected in a similar non-cancer population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>SEER-Medicare linked files were used to identify patients with pancreatic adenocarcinoma. Cancer diagnoses were considered to be \u201ctimely\u201d if within 2\u00a0months of cholecystectomy or \u201cdelayed\u201d if 2-12\u00a0months after cholecystectomy. Clinical factors and survival outcomes were compared using chi-square and Kaplan-Meier analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Rate of cholecystectomy in the year prior to diagnosis of cancer was 1.9% for the cancer group, compared to .4% in the non-cancer group (OR = 4.7, 95% CI 4.4-5.1). Differences in the cancer vs non-cancer cohorts at the time of cholecystectomy included a higher age (74 vs 70, P &lt; .0001), more males (49.9% vs 41.7%, P &lt; .0001), and more frequent open technique (21.0% vs 9.4%, P &lt; .0001). Acute pancreatitis was nearly twice as common in the cancer cohort (19.1%) vs the non-cancer cohort (10.7%), P &lt; .0001. There were no differences between patients who had a timely diagnosis after cholecystectomy compared to a delayed diagnosis with regard to age, gender, comorbidity index, race, or rural\/urban designation. The rates of localized disease and subsequent resection were also similar between the delayed and timely groups. Overall unadjusted survival was no different between timely and delayed diagnoses, P = .96.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Elderly patients diagnosed with pancreatic adenocarcinoma are more likely to have had a recent cholecystectomy compared to those without.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348241227165","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T04:52:22Z","timestamp":1704948742000},"page":"1195-1201","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis of Pancreatic Cancer after Cholecystectomy in the Elderly"],"prefix":"10.1177","volume":"90","author":[{"given":"Marc W.","family":"Fromer","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-9317","authenticated-orcid":false,"given":"Mackenzie L.","family":"Shindorf","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler J.","family":"Mouw","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiying","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Myers","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yana","family":"Feygin","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indranil","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Robert C. G.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly M.","family":"McMasters","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prejesh","family":"Philips","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Scoggins","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. T.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E.","family":"Egger","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Louisville, Louisville, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"bibr1-00031348241227165","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"bibr2-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31551"},{"key":"bibr3-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2012.12.002"},{"key":"bibr4-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1007\/BF02712816"},{"key":"bibr5-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000527"},{"key":"bibr6-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-015-2923-z"},{"key":"bibr7-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1080\/003655202762671323"},{"key":"bibr8-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1177\/000313480807400706"},{"key":"bibr9-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69044-2"},{"key":"bibr10-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1038\/nature09515"},{"key":"bibr11-00031348241227165","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.02.004"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348241227165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348241227165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348241227165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:38:54Z","timestamp":1777379934000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348241227165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1177\/00031348241227165"],"URL":"https:\/\/doi.org\/10.1177\/00031348241227165","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,11]]}}}