{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T02:17:50Z","timestamp":1784859470841,"version":"3.55.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prolonged postoperative ileus (PPOI) contributes to morbidity and prolonged hospitalization. Prucalopride, a selective 5-hydroxytryptamine receptor agonist, may enhance bowel motility. This review assesses whether the perioperative use of prucalopride compared to placebo is associated with accelerated return of bowel function post gastrointestinal (GI) surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>OVID, CENTRAL, and EMBASE were searched as of January 2024 to identify randomized controlled trials (RCTs) comparing prucalopride and placebo for prevention of PPOI in adult patients undergoing GI surgery. The primary outcomes were time to stool, time to flatus, and time to oral tolerance. The secondary outcomes were incidence of PPOI, length of stay (LOS), postoperative complications, adverse events, and overall costs. The Cochrane risk of bias tool for randomized trials and the Grading of Recommendations, Assessment, Development, and Evaluations framework were used. An inverse variance random effects model was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From 174 citations, 3 RCTs with 139 patients in each treatment group were included. Patients underwent a variety of GI surgeries. Patients treated with prucalopride had a decreased time to stool (mean difference 36.82 hours, 95% CI 59.4 to 14.24 hours lower, I\n                      <jats:sup>2<\/jats:sup>\n                      = 62%, low certainty evidence). Other outcomes were not statistically significantly different (very low certainty evidence). Postoperative complications and adverse events could not be meta-analyzed due to heterogeneity; yet individual studies suggested no significant differences (very low certainty evidence).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Current RCT evidence suggests that prucalopride may enhance postoperative return of bowel function. Larger RCTs assessing patient important outcomes and associated costs are needed before routine use of this agent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348241241683","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T13:04:55Z","timestamp":1711458295000},"page":"1682-1701","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Prucalopride and Bowel Function Post Gastrointestinal Surgery: Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1177","volume":"90","author":[{"given":"Gaurav","family":"Talwar","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of General Surgery, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8268-014X","authenticated-orcid":false,"given":"Sahil","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General Surgery, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"McKechnie","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General Surgery, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuling","family":"Yang","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jigish","family":"Khamar","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General Surgery, McMaster University, Hamilton, ON, Canada"},{"name":"Department of Surgery, Division of General Surgery, St. Joseph\u2019s Healthcare, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristithes","family":"Doumouras","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General Surgery, McMaster University, Hamilton, ON, Canada"},{"name":"Department of Surgery, Division of General Surgery, St. Joseph\u2019s Healthcare, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagla","family":"Eskicioglu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of General Surgery, McMaster University, Hamilton, ON, Canada"},{"name":"Department of Surgery, Division of General Surgery, St. Joseph\u2019s Healthcare, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"bibr1-00031348241241683","unstructured":"Townsend JCM, Beauchamp RD, Evers BM, Mattox KL. 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Health Canada, The Drug and Health Product Register\n                      . Ontario, Canada; Bureau of Gastroenterology Infection and Viral Diseases (BGIVD) (2021). Retrieved from the Health Canada website: https:\/\/hpr-rps.hres.ca\/reg-content\/regulatory-decision-summary-detailTwo.php?lang=en&linkID=RDS00231"},{"key":"bibr19-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002381"},{"key":"bibr20-00031348241241683","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.583422"},{"key":"bibr21-00031348241241683","volume-title":"Health Canada, the drug and Health Product register","author":"Details for: Apo-Prucalopride","year":"2021"},{"key":"bibr22-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X17734809"},{"key":"bibr23-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1668927"},{"key":"bibr24-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41698-w"},{"key":"bibr25-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317263"},{"key":"bibr26-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13557"},{"key":"bibr27-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac121"},{"key":"bibr28-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"bibr29-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-4354-3_3"},{"key":"bibr30-00031348241241683","first-page":"366","volume":"2019","author":"Sterne JA","year":"2019","journal-title":"BMJ"},{"key":"bibr31-00031348241241683","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022)","author":"Higgins JPT","year":"2022"},{"key":"bibr32-00031348241241683","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022)","author":"Sch\u00fcnemann HJ","year":"2022"},{"key":"bibr33-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1351137"},{"issue":"1","key":"bibr34-00031348241241683","first-page":"zrab032","volume":"5","author":"EuroSurg Collaborative, &amp; EuroSurg Collaborative","year":"2021","journal-title":"BJS Open"},{"key":"bibr35-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2013.06.004"},{"key":"bibr36-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1002\/bjs5.67"},{"key":"bibr37-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.000621"},{"key":"bibr38-00031348241241683","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135"},{"key":"bibr39-00031348241241683","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022)","author":"Deeks JJ","year":"2022"},{"key":"bibr40-00031348241241683","volume-title":"Interrater reliability: The kappa statistic. 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