{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:49:35Z","timestamp":1777448975688,"version":"3.51.4"},"reference-count":5,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>The utility of 4-factor prothrombin complex concentrate (4F-PCC) for reversal in patients on factor Xa inhibitors (XaI) is unclear, specifically in mild traumatic brain injury (mTBI). This is a retrospective review over 6 years at a level 1 trauma center of patients presenting with mTBI on XaI comparing outcomes for those that received 4F-PCC to those that did not. 140 patients were included, 103 (74%) of these patients received 4F-PCC while 37 (26%) did not. There was no significant difference in neurologic decline within 48 hours of admission or need for neurosurgical intervention. Interestingly, there was no difference in ICH progression (16% vs 14%, P = .77). In this study, 4F-PCC given after mild traumatic brain injury did not impact ICH progression, neurologic decline, or need for neurosurgical intervention. Although limited in numbers, this study suggests that 4F-PCC is not necessarily required in mTBI and further studies are indicated.<\/jats:p>","DOI":"10.1177\/00031348241241726","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T04:55:47Z","timestamp":1711601747000},"page":"1904-1906","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of 4-Factor Prothrombin Complex Concentrate to Reverse Factor Xa Inhibitors in Patients With Traumatic Intracranial Hemorrhage"],"prefix":"10.1177","volume":"90","author":[{"given":"Jessica L.","family":"Rauh","sequence":"first","affiliation":[{"name":"General Surgery, Wake Forest School of Medicine, Winston Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taron","family":"Torosian","sequence":"additional","affiliation":[{"name":"General Surgery, Wake Forest School of Medicine, Winston Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anothony","family":"Thompson","sequence":"additional","affiliation":[{"name":"Radiology, Wake Forest School of Medicine, Winston Salem, NC,USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meagan","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Novant New Hanover Regional Medical Center, Wilmington, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Hoth","sequence":"additional","affiliation":[{"name":"General Surgery, Wake Forest School of Medicine, Winston Salem, NC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"bibr1-00031348241241726","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-019-01846-5"},{"key":"bibr2-00031348241241726","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002283"},{"key":"bibr3-00031348241241726","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045769"},{"key":"bibr4-00031348241241726","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team"},{"key":"bibr5-00031348241241726","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-782060"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348241241726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348241241726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348241241726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:39:39Z","timestamp":1777379979000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348241241726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/00031348241241726"],"URL":"https:\/\/doi.org\/10.1177\/00031348241241726","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]}}}