{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:01:30Z","timestamp":1791896490976,"version":"4.3.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inflammatory bowel diseases (IBDs) pose an increased risk of gastrointestinal cancer with especially worse prognosis. Cytoreductive surgery and heated intraperitoneal chemotherapy (CRS\/HIPEC) improves outcomes in selected patients with colorectal peritoneal metastases. Little published data describes the outcomes of CRS\/HIPEC in IBD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of a prospectively maintained CRS\/HIPEC database. Outcomes in patients with and without IBD were compared for short-term outcomes such as hospital\/intensive care unit stay, blood loss\/transfusions, complications, and reoperations. We also examined oncological outcomes including recurrence, overall (OS), and disease-free survival (DFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 232 patients that underwent CRS\/HIPEC for colorectal or small bowel adenocarcinoma, of which 10 were with IBD. Patients with IBD had lower ASA ( p=0.005), less hypertension ( p=0.033), and 30% small bowel primary compared to none in the non-IBD cohort ( p&lt;0.001). Otherwise, demographic and perioperative characteristics were similar between the groups. The median peritoneal cancer index (PCI) was 7 and similar between the cohorts ( p=0.422). Extent of organ resections and peritonectomies performed were similar. Complications occurred in 60.3% of patients (21.2% major), similar between the groups ( p=0.744 and p=0.444, respectively). Reoperation rate of 27% was similar between groups ( p=0.097). The median OS in the IBD cohort was 19.6 vs 53.2 months in the non-IBD cohort ( p = 0.056). The median DFS in the IBD cohort was 4.9 vs 9.4 months in the non-IBD cohort ( p=0.174).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Cytoreductive surgery and heated intraperitoneal chemotherapy in patients with IBD has similar complication profile and trended towards poorer oncological outcomes as CRS\/HIPEC in non-IBD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348241257471","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T14:35:15Z","timestamp":1716993315000},"page":"2876-2884","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Inflammatory Bowel Disease in Cytoreductive Surgery and Heated Intraperitoneal Chemotherapy"],"prefix":"10.1177","volume":"90","author":[{"given":"Almog","family":"Ben-Yaacov","sequence":"first","affiliation":[{"name":"Department of General Surgery, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gal","family":"Schtrechman","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Adileh","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Surgery, Edith Wolfson Medical Center, Holon, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Beller","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naama","family":"Halpern","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Margalit","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Ben-Yacov","sequence":"additional","affiliation":[{"name":"Department of Surgery, Edith Wolfson Medical Center, Holon, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviram","family":"Nissan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sheba Medical Center, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6629-453X","authenticated-orcid":false,"given":"Shachar","family":"Laks","sequence":"additional","affiliation":[{"name":"Department of Surgery, Edith Wolfson Medical Center, Holon, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,29]]},"reference":[{"key":"bibr1-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.526"},{"key":"bibr2-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010215)91:4<854::aid-cncr1073>3.0.co;2-z"},{"key":"bibr3-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.249"},{"key":"bibr4-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828029c0"},{"key":"bibr5-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.22935"},{"key":"bibr6-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21380"},{"key":"bibr7-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt591"},{"key":"bibr8-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0142(20000115)88:2<358::aid-cncr16>3.0.co;2-o"},{"key":"bibr9-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.1039"},{"key":"bibr10-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.187"},{"key":"bibr11-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.012"},{"key":"bibr12-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30599-4"},{"key":"bibr13-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1515\/pp-2022-0121"},{"key":"bibr14-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.03.006"},{"key":"bibr15-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"bibr16-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199501000-00004"},{"key":"bibr17-00031348241257471","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2525"}],"container-title":["The 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