{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:33:51Z","timestamp":1777448031918,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the prognostic value of systematic inflammatory response in patients with lymph node-negative colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively investigated 245 patients with lymph node-negative colorectal cancer who underwent curative resection and evaluated the prognostic impact of systematic inflammatory response, which was represented by neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and C-reactive protein-to-albumin ratio (CAR). Then, the prognostic significance of the systematic inflammatory response on survival was analyzed using the Kaplan-Meier method in patients selected by propensity score matching (PSM) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the multivariate analysis, CAR \u2265 .081 ( P = .004) was independent predictors of disease-free survival, while American Society of Anesthesiologists physical status \u22653 ( P = .049) and CAR \u2265 .081 ( P &lt; .001) were independent predictors of overall survival. By PSM analysis, PSM-high-CAR was significantly associated with worse disease-free survival ( P = .043) and overall survival ( P = .041) in patients with lymph node-negative colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>C-reactive protein-to-albumin ratio may be a significant indicator of poor long-term outcomes in patients with lymph node-negative colorectal cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348241262430","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T05:53:28Z","timestamp":1718603608000},"page":"3031-3037","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Systemic Inflammatory Response in Lymph Node-Negative Colorectal Cancer"],"prefix":"10.1177","volume":"90","author":[{"given":"Yasuhiro","family":"Takano","sequence":"first","affiliation":[{"name":"Department of Surgery, Tokyo Generel Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Kubota","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kasai Shoikai Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Kai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Generel Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Kodera","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kasai Shoikai Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneyuki","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kasai Shoikai Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunobu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Generel Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Generel Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyoshi","family":"Hanyu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Tokyo Generel Hospital, Tokyo, 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