{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T13:29:29Z","timestamp":1786886969395,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Optimal utilization of vasopressors during early post-injury resuscitation remains unclear. Our study aims to describe the relationship between the timing of vasopressor administration and outcomes among hypotensive trauma patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective analysis of the 2017-2018 ACS-TQIP database. We included adult (\u226518\u00a0years) trauma patients presenting with hypotension (lowest SBP &lt;90\u00a0mmHg) who received vasopressors within 6\u00a0hours of admission. We excluded patients who had a severe head injury (Head-AIS &gt;3) and those with spinal cord injury (Spine-AIS &gt;3). Patients were stratified based on the time to receive vasopressors. Multivariable regression analyses were performed to identify the independent association between timing of vasopressor initiation and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>1049 patients were identified. Mean age was 55 \u00b1 20\u00a0years, and 70% of patients were male. The median ISS was 16 [9-24], 80% had a blunt injury, and the mean SBP was 61 \u00b1 24\u00a0mmHg. The median time to first vasopressor administration was 319 [68-352] minutes. Overall, 24-hour and in-hospital mortality rates were 19% and 33%, respectively. Every one-hour delay in vasopressor administration beyond the first hour was independently associated with decreased odds of 24-hour mortality (aOR: 0.65, P &lt; 0.001), in-hospital mortality (aOR: 0.65, P &lt; 0.001), major complications (aOR: 0.77, P = 0.003), and increased odds of longer ICU LOS (\u03b2 + 2.53, P = 0.012). There were no associations between the timing of early vasopressor administration and 24-hour PRBC transfusion requirements ( P &gt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Earlier vasopressor requirement among hypotensive trauma patients was independently associated with increased mortality and major complications. Further research on the utility and optimal timing of vasopressors during the post-injury resuscitative period is warranted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence<\/jats:title>\n                    <jats:p>III therapeutic\/care management<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348241269425","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:59:11Z","timestamp":1722355151000},"page":"22-30","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Vasopressor Requirement Among Hypotensive Trauma Patients: Does It Cause More Harm Than Good?"],"prefix":"10.1177","volume":"91","author":[{"given":"Tanya","family":"Anand","sequence":"first","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Hejazi","sequence":"additional","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Nelson","sequence":"additional","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7246-7366","authenticated-orcid":false,"given":"Ben","family":"Litmanovich","sequence":"additional","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-6929","authenticated-orcid":false,"given":"Audrey L.","family":"Spencer","sequence":"additional","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0878-7923","authenticated-orcid":false,"given":"Muhammad Haris","family":"Khurshid","sequence":"additional","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshin","family":"Ghaedi","sequence":"additional","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Hosseinpour","sequence":"additional","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J.","family":"Magnotti","sequence":"additional","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2205-3061","authenticated-orcid":false,"given":"Bellal","family":"Joseph","sequence":"additional","affiliation":[{"name":"Division of Trauma, Critical Care, Burns, and Emergency Surgery, Department of Surgery, College of Medicine, University of Arizona, Tucson, AZ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"bibr1-00031348241269425","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1705649"},{"key":"bibr2-00031348241269425","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2020.05.008"},{"key":"bibr3-00031348241269425","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06933-x"},{"key":"bibr4-00031348241269425","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000004617"},{"key":"bibr5-00031348241269425","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-3-13"},{"key":"bibr6-00031348241269425","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.2884"},{"key":"bibr7-00031348241269425","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.02.062"},{"key":"bibr8-00031348241269425","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31815dd029"},{"issue":"3","key":"bibr9-00031348241269425","first-page":"428","volume":"31","author":"Senthilkumaran 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M, Hjortrup PB, Pettil\u00e4 V. Vasopressors in shock: are we meeting our target and do we really understand what we are aiming at? Berlin, Germany: Springer; 2016:1176-1178.","DOI":"10.1007\/s00134-016-4269-8"},{"key":"bibr28-00031348241269425","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.894270"},{"key":"bibr29-00031348241269425","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-022-02045-3"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348241269425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348241269425","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348241269425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:36:52Z","timestamp":1777379812000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348241269425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1177\/00031348241269425"],"URL":"https:\/\/doi.org\/10.1177\/00031348241269425","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]}}}