{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:35:15Z","timestamp":1777448115886,"version":"3.51.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The School of Medicine Pilot Grant"},{"name":"The Tulane University Bridge Fund"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Background: Surgery is the definitive treatment option for tertiary hyperparathyroidism (THPT), however, the optimal surgical approach remains unclear. We aimed to compare total parathyroidectomy (PTX) with auto-transplantation vs subtotal PTX for THPT through a systematic review and meta-analysis.<\/jats:p>\n                  <jats:p>Methods: PubMed, Embase, and Web of Science were searched for studies comparing outcomes of total vs subtotal PTX for THPT. A total of 28 studies (n = 1000 patients) met the inclusion criteria.<\/jats:p>\n                  <jats:p>Results: The mean age was 46.5\u00a0years and 53% were female. The proportion of females (59% vs 49%) was higher in the total PTX with auto-transplantation cohort ( P = .008). Both procedures had similar preoperative calcium and PTH levels. Postoperative and 6-month calcium and PTH were also comparable between groups, except transiently higher post-operative PTH in the total PTX with auto-transplantation cohort ( P = .03). Hypercalcemia cure rates were 98%-100% with no difference between surgical techniques ( P = .67). Safety profiles were comparable and low.<\/jats:p>\n                  <jats:p>Conclusions: Total PTX with auto-transplantation and subtotal PTX yield similar efficacy and safety for THPT, with no significant differences in cure rates, recurrence, complications, or biochemical control.<\/jats:p>","DOI":"10.1177\/00031348241290615","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T18:42:36Z","timestamp":1728672156000},"page":"242-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Subtotal Versus Total Parathyroidectomy for the Management of Tertiary Hyperparathyroidism: A Systematic Literature Review and Meta-Analysis of Optimal Surgical Modality"],"prefix":"10.1177","volume":"91","author":[{"given":"Aaron L.","family":"Albuck","sequence":"first","affiliation":[{"name":"Department of Surgery, Tulane University School of Medicine, New Orleans, LA, 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