{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:36:53Z","timestamp":1777448213575,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of this systematic review was to assess the safety and effectiveness of beta antagonists for improving clinical care in burn patients, compared to placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Articles from randomized-controlled trials were identified by a literature search on PubMed and Cochrane. We included relevant trials involving patients with burn. Trials were eligible if they evaluated propranolol and compared to usual care or placebo. We conducted a meta-analysis using a random-effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 2114 patients were included from 14 RCTs. Beta-blocker-treated patients had decreased heart rates (WMD = \u221214.73, 95% CIs = [\u221219.14, \u221210.32]), mean arterial pressure (WMD = \u22122.76, 95% CIs = [\u22123.81, \u22121.70]), rate pressure product (WMD = \u22121.13, 95% CIs = [\u22121.56, \u22120.71]), reduced time for wound healing (WMD = \u22125.08, 95% CIs [\u22128.97, \u22121.18]), and lower resting energy expenditure (WMD = \u2212168.83, 95% CIs [\u2212232.03, \u2212105.63]). However, use of beta-blockers did not reduce mortality rate (WMD = 0.98, 95% CIs [0.68, 1.41]), incidence of sepsis (RR = 0.82, 95% CIs = [0.50, 1.35]), or length of stay in hospital (WMD = \u22121.50, 95% CIs [\u22124.76, 1.77]) compared with placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that the administration of propranolol to burned patients does not contribute to increased mortality rates, reduced length of hospital stays, or heightened sepsis occurrence. It demonstrates a protective effect on heart function by reducing heart rate, resting energy expenditure, rate pressure product, and wound healing. More randomized-controlled and multi-center studies are needed to effectively establish the use of beta antagonists in burn patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348251313991","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T14:57:16Z","timestamp":1736521036000},"page":"772-783","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effectiveness and Safety of Beta Antagonists in Patients With Burns: An Updated Meta-Analysis"],"prefix":"10.1177","volume":"91","author":[{"given":"Aribah","family":"Bhatti","sequence":"first","affiliation":[{"name":"Department of Medicine, Dow Medical College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8821-471X","authenticated-orcid":false,"given":"Sanaullah","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2352-9326","authenticated-orcid":false,"given":"Muhammad","family":"Shahzaib","sequence":"additional","affiliation":[{"name":"Department of Medicine, Karachi Medical &amp; Dental College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9719-7833","authenticated-orcid":false,"given":"Muhamad Amaan","family":"Nadeem","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ziauddin Medical College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asim","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dow Medical College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habib Ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ziauddin Medical College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4204-059X","authenticated-orcid":false,"given":"Syed Saaid","family":"Rizvi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maimoona","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Liaquat National Hospital and Medical College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasninder Dhaliwal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California, Riverside, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Mahfooz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Parkview Health System, Pueblo, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rameel Muhammad","family":"Aftab","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ziauddin Medical College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dua Fatima Zaheer","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jinnah Sindh Medical University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Azhar","family":"Chachar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ziauddin Medical College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-13887-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181856241"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010342"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-017-0124-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0913-x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.10.019"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e318166d414"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318265427e"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.05.015"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000671"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2021.08.024"},{"issue":"6","key":"e_1_3_3_13_2","first-page":"1013","article-title":"Efficacy of propranolol in wound healing for hospitalized burn patients","volume":"30","author":"Mohammadi AA","year":"2009","unstructured":"Mohammadi AA, Bakhshaeekia A, Alibeigi P, et al. Efficacy of propranolol in wound healing for hospitalized burn patients. J Burn Care Res. 2009;30(6):1013-1017.","journal-title":"J Burn Care Res"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2020.01.46"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200210000-00007"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318031afd3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001844"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13478"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1121444"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)91500-9"},{"issue":"2","key":"e_1_3_3_21_2","first-page":"101","article-title":"Systematic review of the effect of propanolol on hypermetabolism in burn injuries","volume":"39","author":"N\u00fa\u00f1ez-Villaveir\u00e1n T","year":"2015","unstructured":"N\u00fa\u00f1ez-Villaveir\u00e1n T, S\u00e1nchez M, Mill\u00e1n P, Garc\u00eda-de-Lorenzo A. Systematic review of the effect of propanolol on hypermetabolism in burn injuries. Med Intensiva. 2015;39(2):101-113.","journal-title":"Med Intensiva"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348251313991","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348251313991","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348251313991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:37:19Z","timestamp":1777379839000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348251313991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1177\/00031348251313991"],"URL":"https:\/\/doi.org\/10.1177\/00031348251313991","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,10]]}}}