{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:44:02Z","timestamp":1777448642872,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:00:00Z","timestamp":1757548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA106183"],"award-info":[{"award-number":["T32CA106183"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laboratory biomarkers have been used as prognostic markers in several solid tumors. This study aims to evaluate 3 preoperatively measured laboratory values: blood neutrophil to lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), as potential prognostic biomarkers in patients with peritoneal carcinomatosis undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective review of 156 patients who underwent CRS-HIPEC between 2013 and 2020. Biomarker ratios were calculated based on the preoperative laboratory values closest to the date of CRS-HIPEC. Multivariable Cox regression models were used to evaluate the biomarkers\u2019 associations with survival (OS), recurrence-free survival (RFS), and postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Increased MLR was independently associated with worse OS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and RFS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) in this patient cohort. Additionally, increased MLR was independently associated with increased rate of hospital re-admission within 30 days after discharge (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). None of the analyzed biomarkers were associated with increased rate of Clavien-Dindo class III\/IV complication or hospital length of stay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this retrospective review, increased preoperative MLR was independently associated with worse overall and recurrence-free survival as well as increased rate of hospital re-admission. Preoperative PLR was associated with increased hospital length of stay. Thus, the utilization of preoperative systemic inflammatory biomarkers may aid in preoperative counseling and risk stratification prior to CRS-HIPEC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348251378909","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:28:48Z","timestamp":1757618928000},"page":"492-499","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Systemic Inflammatory Biomarkers in Patients Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy"],"prefix":"10.1177","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2530-0328","authenticated-orcid":false,"given":"David N.","family":"Hanna","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad O.","family":"Ghani","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Mina","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Hermina","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics"},{"name":"Vanderbilt University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Biostatistics"},{"name":"Vanderbilt University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina E.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Idrees","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepa","family":"Magge","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,9,11]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25116"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.419"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.187"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2017.1367846"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.12.048"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3869-1"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182a62b0d"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3611"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29050276"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6420"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.06.006"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju124"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.15405"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11185318"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S140118"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8050589"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5176-5"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-12736-1"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2017.1384073"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2019.12.008"},{"key":"e_1_3_4_23_2","first-page":"483","article-title":"Immunotherapy of peritoneal carcinomatosis","volume":"134","author":"Strohlein MA","year":"2007","unstructured":"Strohlein MA, Heiss MM. Immunotherapy of peritoneal carcinomatosis. Cancer Treat Res. 2007;134:483-491.","journal-title":"Cancer Treat Res"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147260"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36310-9"}],"container-title":["The American Surgeon\u2122"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348251378909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/00031348251378909","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/00031348251378909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:38:29Z","timestamp":1777379909000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/00031348251378909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,11]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1177\/00031348251378909"],"URL":"https:\/\/doi.org\/10.1177\/00031348251378909","relation":{},"ISSN":["0003-1348","1555-9823"],"issn-type":[{"value":"0003-1348","type":"print"},{"value":"1555-9823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,11]]}}}