{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:08:51Z","timestamp":1788847731209,"version":"build-2803163510"},"reference-count":42,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M734298"],"award-info":[{"award-number":["2023M734298"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Project Plan of Liaoning Province","award":["2023\u2010MSLH\u2010354"],"award-info":[{"award-number":["2023\u2010MSLH\u2010354"]}]},{"name":"Key Research and Development Program Project of Mudanjiang","award":["HA25CY059"],"award-info":[{"award-number":["HA25CY059"]}]},{"name":"2024 Annual Basic Research Funding Project for Provincial Higher Education Institutions of Heilongjiang Province","award":["2024-KYYWF-0514"],"award-info":[{"award-number":["2024-KYYWF-0514"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["The American Surgeon\u2122"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to examine risk factors associated with the progression of pyogenic liver abscess (PLA) to sepsis and to evaluate their predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on patients diagnosed with PLA at a single institution between January 2019 and December 2024. Demographic data and laboratory parameters were collected. Based on the occurrence of sepsis, patients were categorized into a sepsis group (n = 73) and a non-sepsis group (n = 103). Multivariate logistic regression analysis was used to determine independent risk factors for progression to sepsis. Receiver operating characteristic (ROC) curve analysis was conducted to assess the predictive performance of the identified factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multivariate logistic regression identified uric acid (UA), total bilirubin (TBIL), and platelet count (PLT) as independent risk factors for the progression of PLA to sepsis. ROC analysis yielded the following results: (1) Sensitivity: UA 0.589, TBIL 0.753, PLT 0.726; (2) Specificity: UA 0.806, TBIL 0.913, PLT 0.704; (3) Threshold: UA 306.5\u00a0\u03bcmol\/L, TBIL 26.75\u00a0\u03bcmol\/L, PLT 155 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Multivariate analysis identified elevated UA (per 1\u00a0\u03bcmol\/L increase: OR 1.006, 95% CI 1.000-1.012) and TBIL (per 1\u00a0\u03bcmol\/L increase: OR 1.301, 95% CI 1.183-1.478), and decreased PLT (per 1 \u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L decrease: OR 0.982, 95% CI 0.972-0.989) as independent risk factors for sepsis progression. Threshold values of UA \u2265306.5\u00a0\u03bcmol\/L, TBIL \u226526.75\u00a0\u03bcmol\/L, and PLT \u2264155 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L may serve as clinical indicators for identifying patients at high risk of progression to sepsis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/00031348261451738","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:51:32Z","timestamp":1778529092000},"page":"2613-2623","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for the Progression of Pyogenic Liver Abscess to Sepsis and Development of a Predictive Model"],"prefix":"10.1177","volume":"92","author":[{"given":"Xianzhi","family":"Cheng","sequence":"first","affiliation":[{"name":"Hongqi Hospital Affiliated to Mudanjiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Wang","sequence":"additional","affiliation":[{"name":"Hongqi Hospital Affiliated to Mudanjiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hongqi Hospital Affiliated to Mudanjiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[{"name":"The Fourth Affiliated Hospital of Harbin Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzi","family":"Cong","sequence":"additional","affiliation":[{"name":"Hongqi Hospital Affiliated to Mudanjiang Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Mudanjiang Food and Drug Inspection and Testing Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5278-6053","authenticated-orcid":false,"given":"Xi","family":"Zeng","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_3_6_2_2","volume-title":"StatPearls [Internet]. 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